ArticleJournal of medical microbiology2016
Microbial profiling of dental plaque from mechanically ventilated patients.
Article in Journal of medical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia.The Cochrane database of systematic reviews · 2020Pooled it
- Combination of toothbrushing and chlorhexidine compared with exclusive use of chlorhexidine to reduce the risk of ventilator-associated pneumonia: A systematic review with meta-analysis.Clinics (Sao Paulo, Brazil)Pooled it
- Evaluation of the relationship between quorum sensing system genes and antibiotic resistance in isolatedIranian journal of microbiology · 2025Article
- In vitro investigation of relationship between quorum-sensing system genes, biofilm forming ability, and drug resistance in clinical isolates of Pseudomonas aeruginosa.BMC microbiology · 2024Article
- Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management.Pharmaceuticals (Basel, Switzerland) · 2024Article
- The gut microbiota composition is linked to subsequent occurrence of ventilator-associated pneumonia in critically ill patients.Microbiology spectrum · 2023Article
- Prevalence of oral complications in the course of severe SARS-CoV-2 infection under mechanical non-invasive ventilation.European journal of medical research · 2023Article
- Simultaneous Analysis of Bacterial and Fungal Communities in Oral Samples from Intubated Patients in Intensive Care Unit.Diagnostics (Basel, Switzerland) · 2023Article
- Impact of tooth brushing on oral bacteriota and health care-associated infections among ventilated COVID-19 patients: an intervention study.Antimicrobial resistance and infection control · 2023Article
- Time-dependent microbial shifts during crayfish decomposition in freshwater and sediment under different environmental conditions.Scientific reports · 2023Article
- Occurrence of plasmid-mediated quinolone resistance genes in Pseudomonas aeruginosa strains isolated from clinical specimens in southwest Iran: a multicentral study.Scientific reports · 2022Article
- Identifying oral disease variables associated with pneumonia emergence by application of machine learning to integrated medical and dental big data to inform eHealth approaches.Frontiers in dental medicine · 2022Article
- Oral health care for the critically ill: a narrative review.Critical care (London, England) · 2021Review
- Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis.Annual review of microbiology · 2019Review
- Association between oral health and upper respiratory tract infection among children.International dental journal · 2018Article
- Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection.Physiological reviews · 2018Review
- Clinical validation and assessment of a modular fluorescent imaging system and algorithm for rapid detection and quantification of dental plaque.BMC oral health · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micro-organisms isolated from the oral cavity may translocate to the lower airways during mechanical ventilation (MV) leading to ventilator-associated pneumonia (VAP). Changes within the dental plaque microbiome during MV have been documented previously, primarily using culture-based techniques. The aim of this study was to use community profiling by high throughput sequencing to comprehensively analyse suggested microbial changes within dental plaque during MV. Bacterial 16S rDNA gene sequences were obtained from 38 samples of dental plaque sampled from 13 mechanically ventilated patients and sequenced using the Illumina platform. Sequences were processed using Mothur, applying a 97% gene similarity cut-off for bacterial species level identifications. A significant 'microbial shift' occurred in the microbial community of dental plaque during MV for nine out of 13 patients. Following extubation, or removal of the endotracheal tube that facilitates ventilation, sampling revealed a decrease in the relative abundance of potential respiratory pathogens and a compositional change towards a more predominantly (in terms of abundance) oral microbiota including Prevotella spp., and streptococci. The results highlight the need to better understand microbial shifts in the oral microbiome in the development of strategies to reduce VAP, and may have implications for the development of other forms of pneumonia such as community-acquired infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.