Evidence map›Paper›PMID 26690588›Full record

ArticlePsychopharmacology2016

Responding for a conditioned reinforcer or unconditioned sensory reinforcer in mice: interactions with environmental enrichment, social isolation, and monoamine reuptake inhibitors.

Caleb J Browne, Paul J Fletcher, Fiona D Zeeb

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter: Role of the 5-HT2C Receptor.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Caleb J BrowneDepartment of Psychology, University of Toronto, 100 St. George Street, Toronto, ON, Canada, M5S 3G3. caleb.browne@mail.utoronto.ca.
Paul J FletcherDepartment of Psychology, University of Toronto, 100 St. George Street, Toronto, ON, Canada, M5S 3G3.
Fiona D ZeebDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
University of Toronto · CAMental Health Research Canada · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

rationaleEnvironmental factors influence the etiology of many psychiatric disorders. Likewise, environmental factors can alter processes central to motivation. Therefore, motivational deficits present in many disorders may be influenced by early life environmental conditions.

objectiveWe examined whether housing animals in different environmental conditions influenced the ability of sensory stimuli to acquire incentive value and whether elevated monoamine activity altered responsing for these stimuli.

methodsIsolation-housed (IH), pair-housed (PH), and environmentally enriched (EE) male C57BL/6N mice were examined in tests of responding for a conditioned reinforcer (CRf) or an unconditioned sensory reinforcer (USRf). The CRf was previously paired with saccharin delivery through Pavlovian conditioning, while the USRf was not conditioned with a reward. Following baseline tests of responding for the CRf or USRf, the effects of elevated monoamine activity were examined.

resultsAt baseline, PH and EE mice responded similarly for the CRf or USRf. IH mice responded more for the CRf but exhibited slower acquisition of responding for the USRf. Administration of citalopram, a serotonin transporter blocker, or atomoxetine, a norepinephrine transporter blocker, decreased responding for the CRf and USRf in all groups. The dopamine transporter blocker GBR 12909 generally increased responding for the CRf and USRf, but further analysis revealed enhanced responding for both reinforcers only in EE mice.

conclusionsBaseline incentive motivation is strongly influenced by the social component of housing conditions. Furthermore, environmental enrichment increased the sensitivity to elevated dopamine activity, while acute elevations in serotonin and norepinephrine inhibit incentive motivation irrespective of housing condition.

Indexed as

EnvironmentReinforcement, PsychologySocial IsolationAdrenergic Uptake InhibitorsAnimalsAtomoxetine HydrochlorideCitalopramConditioning, ClassicalMaleMiceMice, Inbred C57BLMotivationSaccharinSelective Serotonin Reuptake InhibitorsAdrenergic Uptake InhibitorsAtomoxetine HydrochlorideCitalopramSaccharinSelective Serotonin Reuptake InhibitorsConditioned reinforcerDopamineEnvironmental enrichmentIncentive motivationIncentive salienceMonoamineNorepinephrineSensory reinforcerSerotoninSocial isolation

Identifiers

PMID26690588
OpenAlexW2305053314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.