Evidence map›Paper›PMID 26690214›Full record

ReviewNutrients2015

A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action.

Lynne Bell, Daniel J Lamport, Laurie T Butler, Claire M Williams

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03526406 nacompletednot on this mapstarted 2017, after this paper: background citation

Investigation of the Acute and Chronic Cognitive and Mood Effects of CP9700 in Humans

TypeinterventionalSponsorUniversity of ReadingRan2017 to 2019Enrolled60ConditionsCognitive Function, MoodArmsCP9700, Matched Placebo
NCT04075448 nacompletednot on this mapstarted 2019, after this paper: background citation

The Acute Effect of a Walnut Intervention on Cognitive Performance , Brain Activation, and Serum Markers of Inflammation in Young Adults

TypeinterventionalSponsorUniversity of ReadingRan2019 to 2020Enrolled32ConditionsCognitive Change, Mood, Inflammatory Response, Brain Derived Neurotrophic Factor LevelArmsControl, 50 g Walnut
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Effect of Guarana (Nutrients · 2023
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  4. Dietary Flavonoids and Human Cognition: A Meta-Analysis.Molecular nutrition & food research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lynne BellSchool of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights, Reading RG6 6AL, UK. l.bell@pgr.reading.ac.uk.
Daniel J LamportSchool of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights, Reading RG6 6AL, UK. d.j.lamport@reading.ac.uk.
Laurie T ButlerSchool of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights, Reading RG6 6AL, UK. l.t.butler@reading.ac.uk.
Claire M WilliamsSchool of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights, Reading RG6 6AL, UK. claire.williams@reading.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavonoids are polyphenolic compounds found in varying concentrations in many plant-based foods. Recent studies suggest that flavonoids can be beneficial to both cognitive and physiological health. Long term flavonoid supplementation over a period of weeks or months has been extensively investigated and reviewed, particularly with respect to cognitive ageing and neurodegenerative disease. Significantly less focus has been directed towards the short term effects of single doses of flavonoids on cognition. Here, we review 21 such studies with particular emphasis on the subclass and dose of flavonoids administered, the cognitive domains affected by flavonoid supplementation, and the effect size of the response. The emerging evidence suggests that flavonoids may be beneficial to attention, working memory, and psychomotor processing speed in a general population. Episodic memory effects are less well defined and may be restricted to child or older adult populations. The evidence also points towards a dose-dependent effect of flavonoids, but the physiological mechanisms of action remain unclear. Overall, there is encouraging evidence that flavonoid supplementation can benefit cognitive outcomes within an acute time frame of 0-6 h. But larger studies, combining cognitive and physiological measures, are needed to strengthen the evidence base.

Indexed as

Dietary SupplementsAttentionCognitionCognition DisordersFlavonoidsFruitGinkgo bilobaHumansTeaVegetablesFlavonoidsTeacognitioneffect sizeflavonoidmechanismpolyphenol

Identifiers

PMID26690214
PMCPMC4690090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.