Evidence map›Paper›PMID 26690191›Full record

ArticleInternational journal of environmental research and public health2015

Adult Lifespan Cognitive Variability in the Cross-Sectional Cam-CAN Cohort.

Emma Green, Meredith A Shafto, Fiona E Matthews, Cam-Can, Simon R White

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Emma GreenDepartment of Public Health and Primary Care, Cambridge Institute of Public Health, Univeristy of Cambridge, Cambridge CB2-0SR, UK. ep382@medschl.cam.ac.uk.
Meredith A ShaftoCentre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Downing Street, Cambridge CB2-3EB, UK. mshafto@csl.psychol.cam.ac.uk.
Fiona E MatthewsMRC Biostatistics Unit, Cambridge CB2-0SR, UK. fiona.matthews@mrc-bsu.cam.ac.uk.
Cam-Can
Simon R WhiteMRC Biostatistics Unit, Cambridge CB2-0SR, UK. simon.white@mrc-bsu.cam.ac.uk.
MRC Biostatistics Unit · GBUniversity of Cambridge · GBMRC Cognition and Brain Sciences Unit · GB

Funding

Biotechnology and Biological Sciences Research Council BB/H008217/1Medical Research Council G0601022Medical Research Council MC_U105292687Medical Research Council MC_U105579215Medical Research Council MC_U105597119Medical Research Council U105292687
6 · The paper itself

Abstract

This study examines variability across the age span in cognitive performance in a cross-sectional, population-based, adult lifespan cohort from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study (n = 2680). A key question we highlight is whether using measures that are designed to detect age-related cognitive pathology may not be sensitive to, or reflective of, individual variability among younger adults. We present three issues that contribute to the debate for and against age-related increases in variability. Firstly, the need to formally define measures of central tendency and measures of variability. Secondly, in addition to the commonly addressed location-confounding (adjusting for covariates) there may exist changes in measures of variability due to confounder sub-groups. Finally, that increases in spread may be a result of floor or ceiling effects; where the measure is not sensitive enough at all ages. From the Cam-CAN study, a large population-based dataset, we demonstrate the existence of variability-confounding for the immediate episodic memory task; and show that increasing variance with age in our general cognitive measures is driven by a ceiling effect in younger age groups.

Indexed as

Cognitive AgingAdolescentAdultAgedAged, 80 and overCognitionCognition DisordersCohort StudiesConfounding Factors, EpidemiologicCross-Sectional StudiesFemaleHumansMaleMemoryMiddle AgedPsychological Testsadult lifespanceiling effectscognitive variabilityepisodic memoryheterogeneityMMSEvariance confoundersverbal fluency

Identifiers

PMID26690191
PMCPMC4690939
OpenAlexW2189453617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.