SynthesisInternational journal of environmental research and public health2015
A Systematic Review and Meta-Regression Analysis of Lung Cancer Risk and Inorganic Arsenic in Drinking Water.
Synthesis in International journal of environmental research and public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Arsenic in Drinking Water and Human Biomonitoring in Eastern Croatia: An Exploratory Environmental Health Study.Journal of xenobiotics · 2026Article
- Lung Cancer Screening and Prevention: Beyond Conventional Strategies in a Rapidly Changing Global Milieu.American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting · 2026Review
- Benchmark dose modeling for epidemiological dose-response assessment using case-control studies.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- A Feasibility Study to Mitigate Arsenic Exposure in Well Water in Oregon.Journal of extension · 2025Article
- An overview of the Be Well Home Health Navigator Program to reduce contaminants in well water: Design and methods.Contemporary clinical trials · 2024Article
- Benchmark dose modeling for epidemiological dose-response assessment using prospective cohort studies.Risk analysis : an official publication of the Society for Risk Analysis · 2024Article
- High Proportion of Arsenic Detected in Bronchoalveolar Fluid among Newly Diagnosed Lung Cancer in Jakarta Indonesia.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Somatic loss of the Y chromosome is associated with arsenic exposure among Bangladeshi men.International journal of epidemiology · 2023Article
- ARSENIC IN DRINKING WATER AND URINE AND ITS RELATIONSHIP WITH MALIGNANT TUMORS OF URINARY TRACT IN OSIJEK-BARANJA COUNTY, CROATIA.Acta clinica Croatica · 2023Article
- Particulate arsenic trioxide induces higher DNA damage and reactive oxygen species than soluble arsenite in lung epithelial cells.Toxicology and applied pharmacology · 2022Article
- BMI changes and the risk of lung cancer in male never-smokers: A prospective cohort study.Cancer medicine · 2022Article
- Curcumin prevents AsChinese medicine · 2021Article
- Rare, Protein-Altering Variants inEnvironmental health perspectives · 2021Article
- Article
- Prostate Cancer Incidence in U.S. Counties and Low Levels of Arsenic in Drinking Water.International journal of environmental research and public health · 2020Article
- Arsenic Drinking Water Violations Decreased across the United States Following Revision of the Maximum Contaminant Level.Environmental science & technology · 2019Article
- Metal carcinogen exposure induces cancer stem cell-like property through epigenetic reprograming: A novel mechanism of metal carcinogenesis.Seminars in cancer biology · 2019Review
- Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults.Environmental health perspectives · 2019Article
- A review of arsenic exposure and lung cancer.Toxicology research · 2019Review
- State of the science review of the health effects of inorganic arsenic: Perspectives for future research.Environmental toxicology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High levels (> 200 µg/L) of inorganic arsenic in drinking water are known to be a cause of human lung cancer, but the evidence at lower levels is uncertain. We have sought the epidemiological studies that have examined the dose-response relationship between arsenic levels in drinking water and the risk of lung cancer over a range that includes both high and low levels of arsenic. Regression analysis, based on six studies identified from an electronic search, examined the relationship between the log of the relative risk and the log of the arsenic exposure over a range of 1-1000 µg/L. The best-fitting continuous meta-regression model was sought and found to be a no-constant linear-quadratic analysis where both the risk and the exposure had been logarithmically transformed. This yielded both a statistically significant positive coefficient for the quadratic term and a statistically significant negative coefficient for the linear term. Sub-analyses by study design yielded results that were similar for both ecological studies and non-ecological studies. Statistically significant X-intercepts consistently found no increased level of risk at approximately 100-150 µg/L arsenic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.