ArticleMolecules (Basel, Switzerland)2015
Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Impact of rhizosphere quantitative microbiome and soil properties on alkaloid levels in Lycoris aurea herb.Scientific reports · 2025Article
- Medicinal compounds and biotechnology of Amaryllidaceae alkaloids inFrontiers in plant science · 2025Review
- A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes.Cell · 2024Article
- Potential medicinal plants involved in inhibiting 3CLJournal of integrative medicine · 2022Review
- Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach.Tetrahedron letters · 2021Article
- A Brief Overview of Potential Treatments for Viral Diseases Using Natural Plant Compounds: The Case of SARS-Cov.Molecules (Basel, Switzerland) · 2021Review
- Galantamine Quantity and Alkaloid Profile in the Bulbs ofMetabolites · 2021Article
- Metabolic Profiling of Primary Metabolites and Galantamine Biosynthesis in WoundedPlants (Basel, Switzerland) · 2020Article
- Chemistry and Biological Activity of Alkaloids from the GenusMolecules (Basel, Switzerland) · 2020Review
- Identification, molecular characterization and expression of JAZ genes in Lycoris aurea.PloS one · 2020Article
- Exploration of Floral Volatile Organic Compounds in Six TypicalPlants (Basel, Switzerland) · 2019Article
- Transcriptome Analysis and Metabolic Profiling ofBiology · 2019Article
- Screening for Natural Inhibitors of Topoisomerases I fromFrontiers in plant science · 2017Article
- Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major active constituents from Amaryllidaceae family were reported to be Amaryllidaceae alkaloids (AAs), which exhibited a wide spectrum of biological activities, such as anti-tumor, anti-viral, and acetyl-cholinesterase-inhibitory activities. In order to better understand their potential as a source of bioactive AAs and the phytochemical variations among three different species of Lycoris herbs, the HPLC fingerprint profiles of Lycoris aurea (L. aurea), L. radiata, and L. guangxiensis were firstly determined and compared using LC-UV and LC-MS/MS. As a result, 39 peaks were resolved and identified as AAs, of which nine peaks were found in common for all these three species, while the other 30 peaks could be revealed as characteristic AAs for L. aurea, L. radiata and L. guangxiensis, respectively. Thus, these AAs can be used as chemical markers for the identification and quality control of these plant species. To further reveal correlations between chemical components and their pharmaceutical activities of these species at the molecular level, the bioactivities of the total AAs from the three plant species were also tested against HepG2 cells with the inhibitory rate at 78.02%, 84.91% and 66.81% for L. aurea, L. radiata and L. guangxiensis, respectively. This study firstly revealed that the three species under investigation were different not only in the types of AAs, but also in their contents, and both contributed to their pharmacological distinctions. To the best of our knowledge, the current research provides the most detailed phytochemical profiles of AAs in these species, and offers valuable information for future valuation and exploitation of these medicinal plants.
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