ArticlePloS one2015
Longitudinal Cerebral Perfusion Change in Transient Global Amnesia Related to Left Posterior Medial Network Disruption.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Disruption in normal correlational patterns of metabolic networks in the limbic circuit during transient global amnesia.Brain communications · 2023Article
- Forgetting the Unforgettable: Transient Global Amnesia Part II: A Clinical Road Map.Journal of clinical medicine · 2022Review
- Forgetting the Unforgettable: Transient Global Amnesia Part I: Pathophysiology and Etiology.Journal of clinical medicine · 2022Review
- Aberrantly higher functional connectivity in the salience network is associated with transient global amnesia.Scientific reports · 2021Article
- Structural Connectivity and Cortical Thickness Alterations in Transient Global Amnesia.AJNR. American journal of neuroradiology · 2020Article
- Relationship between Cytotoxicity in the Hippocampus and an Abnormal High Intensity Area on the Diffusion-weighted Images of Three Patients with Transient Global Amnesia.Internal medicine (Tokyo, Japan) · 2018Article
- Cortical morphology in patients with transient global amnesia.Brain and behavior · 2017Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathophysiology of transient global amnesia (TGA) is not fully understood. Previous studies using single photon emission computed tomography (SPECT) have reported inconclusive results regarding cerebral perfusion. This study was conducted to identify the patterns of regional cerebral blood flow (rCBF) in TGA patients via longitudinal SPECT analysis. An association between the observed SPECT patterns and a pathophysiological mechanism was considered.
methodsBased on the TGA registry database of Seoul National University Bundang Hospital, 22 TGA patients were retrospectively identified. The subjects underwent initial Tc-99m-ethyl cysteinate dimer (ECD) SPECT within 4 days of an amnestic event and underwent follow-up scans approximately 6 months later. The difference in ECD uptake between the two scans was measured via voxel-based whole brain analysis, and the quantified ECD uptake was tested using a paired t-test.
resultsThe TGA patients had significantly decreased cerebral perfusion at the left precuneus (P<0.001, uncorrected) and at the left superior parietal and inferior temporal gyrus according to the voxel-based whole brain analysis (P<0.005, uncorrected). A difference in the quantified ECD uptake between the 2 scans was also found at the left precuneus among the 62 cortical volumes of interest (P = 0.018, Cohen's d = -0.25).
conclusionWe identified left hemispheric lateralized hypoperfusion that may be related to posterior medial network disruption. These findings may be a contributing factor to the pathophysiology of TGA.
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