Evidence map›Paper›PMID 26689569›Full record

SynthesisClinical oral investigations2016

Efficacy of parathyroid hormone supplementation on the osseointegration of implants: a systematic review.

Fawad Javed, Mohammad D Al Amri, Sergio Varela Kellesarian, Abdulaziz A Al-Kheraif, Fahim Vohra, José Luis Calvo-Guirado, Hans Malmstrom, Georgios E Romanos

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06061354 (Bone Microarchitecture and Implant Stabilization in Atrophic Jaws Reconstructed With Bone Grafts Treated With Teriparatide), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06061354 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Bone Microarchitecture and Implant Stabilization in Atrophic Jaws Reconstructed With Bone Grafts Treated With Teriparatide

TypeinterventionalSponsorUniversidad de ValparaisoRan2023 to 2024Enrolled42ConditionsBone RegenerationArmsTeriparatide, Maxillary Sinus Augmentation, Dental Implant Installation, Bone graft
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Fawad JavedDivision of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA. Fawad_Javed@urmc.rochester.edu.
Mohammad D Al AmriDepartment of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Sergio Varela KellesarianDivision of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
Abdulaziz A Al-KheraifDental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, 11541, Saudi Arabia.
Fahim VohraDepartment of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
José Luis Calvo-GuiradoFaculty of Medicine and Dentistry, University of Murcia, Hospital Morales Meseguer, 2° Planta Clínica Odontológica Calle Marques de los Velez S/n, 30007, Murcia, Spain.
Hans MalmstromDivision of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
Georgios E RomanosDivision of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
Eastman Chemical Company (United States) · USKing Saud University · SAGoethe University Frankfurt · DEUniversidad de Murcia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the present systematic review was to assess the efficacy of parathyroid hormone supplementation on the osseointegration of implants.

methodsThe addressed focused question was Does parathyroid hormone supplementation affect osseointegration around implants? Indexed databases were searched from 1965 up to and including April 2015 using various key words including: Bone to implant contact; implant; parathyroid hormone; and osseointegration. Letters to the Editor, case-reports/case-series, historic reviews, commentaries and articles published in languages other than English were excluded. The pattern of the present systematic review was customized to primarily summarize the pertinent data.

resultsEighteen studies fulfilled the eligibility criteria. Evidence was limited to preclinical animal studies only (11 studies in rodents, 4 in dogs and 3 in rabbits). Number of titanium implants placed ranged between 20 and 80 implants. Results from 16 studies showed that PTH supplementation enhanced new bone formation and/or BIC around implants. One study suggests that PTH-coated implants improve BIC and BA. One study showed no significant difference in BIC and new bone formation around implants with PTH hydrogel placement.

conclusionEfficacy of PTH supplementation on osseointegration of implants shows promising results in animal models, however further investigation is necessary to assess the effectiveness in humans.

Indexed as

Dental ImplantsOsseointegrationParathyroid HormoneAnimalsDogsHumansProstheses and ImplantsTitaniumDental ImplantsParathyroid HormoneTitaniumBone to implant contactImplantOsseointegrationParathyroid hormone

Identifiers

PMID26689569
OpenAlexW2281954786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.