Evidence map›Paper›PMID 26689568›Full record

ArticleClinical oral investigations2016

Effect of therapeutic doses of radiotherapy on the organic and inorganic contents of the deciduous enamel: an in vitro study.

Elza Maria de Sá Ferreira, Luis Eduardo Silva Soares, Héliton Spíndola Antunes, Sofia Takeda Uemura, Patrícia da Silva Barbosa, Hélio Augusto Salmon, Giselle Rodrigues de Sant'Anna

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Dose-Dependent Effects of Simulated Clinical Radiotherapy on the Structure and Properties of Root Dentine.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026
    Article
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  6. Susceptibility of gamma-irradiated primary teeth to a cariogenic challenge: an in vitro study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2020
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elza Maria de Sá FerreiraSchool of Dentistry, Universidade Cruzeiro do Sul (Unicsul), R. Galvão Bueno, 868, Liberdade, São Paulo, SP, CEP- 01506-000, Brazil.
Luis Eduardo Silva SoaresResearch and Development Institute, IP&D, Laboratory of Biomedical Vibracional Spectroscopy, LEVB, Universidade do Vale do Paraíba (UNIVAP), São José dos Campos, SP, Brazil. lesoares@univap.br.
Héliton Spíndola AntunesClínicas Oncológicas Integradas (COI), Radiotherapy, Av. das Américas, 6205, loja E, Barra da Tijuca, Rio de Janeiro, RJ, CEP- 22793-080, Brazil.
Sofia Takeda UemuraFaculdade de Odontologia Uniararas (FHO-Uniararas), Cordination of Dental School, Av. Dr. Maximiliano Baruto, 500, Araras, SP, CEP- 13607-339, Brazil.
Patrícia da Silva BarbosaSchool of Dentistry, Universidade Cruzeiro do Sul (Unicsul), R. Galvão Bueno, 868, Liberdade, São Paulo, SP, CEP- 01506-000, Brazil.
Hélio Augusto SalmonClínicas Oncológicas Integradas (COI), Oral Medicine Service, Av. das Américas, 6205, loja E, Barra da Tijuca, Rio de Janeiro, RJ, CEP- 22793-080, Brazil.
Giselle Rodrigues de Sant'AnnaSchool of Dentistry, Universidade Cruzeiro do Sul (Unicsul), R. Galvão Bueno, 868, Liberdade, São Paulo, SP, CEP- 01506-000, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study evaluated the effects of radiotherapy on the composition of deciduous teeth enamel using micro-energy-dispersive X-ray fluorescence and Fourier transform Raman spectroscopy before and after a pH cycling process. MATERIALS AND

methodsTen deciduous molars were sectioned and divided into two groups (n = 10). The radiotherapy group (RT) was irradiated with 54 Gy at 2 Gy/day, 5 days per week for 5 weeks and 2 days, and the normal group (N) was not irradiated. The RT group was evaluated before radiotherapy (RTb), after radiotherapy (RTa), and after radiotherapy and pH cycling (RTc). The normal group was evaluated before (N) and after pH cycling (Nc). The weight percentage (wt%) of calcium (Ca), phosphorus (P), and organic content; the Ca/P ratio; and the integrated area of the Raman bands relative to the organic, carbonate, and phosphate contents were also evaluated.

resultsThe exclusive use of RT reduced the organic content of the enamel (p = 0.000). The RTc group exhibited a decrease in P wt% (p = 0.016), an increase in the Ca/P ratio (p = 0.000), and a reduction in the integrated area of the phosphate band (p = 0.046). An increase in the Ca/P ratio (p = 0.000) and a reduction in the areas of the carbonate and phosphate bands were found in the RTb/RTc treatments.

conclusionsRT application at a therapeutic dose reduced the organic content of the deciduous enamel. CLINICAL RELEVANCE: Preventive measures should be included in the patient treatment protocol because of RT-induced chemical changes to the deciduous enamel.

Indexed as

Dental EnamelHead and Neck NeoplasmsHumansIn Vitro TechniquesMolarSpectrometry, X-Ray EmissionSpectroscopy, Fourier Transform InfraredTooth, DeciduousDeciduous enamelEnergy-dispersive X-ray spectroscopyFourier transform Raman spectroscopyHead and neck cancerRadiotherapy

Identifiers

PMID26689568

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.