ArticleProceedings of the National Academy of Sciences of the United States of America1989
Transient expression of the cholecystokinin gene in male germ cells and accumulation of the peptide in the acrosomal granule: possible role of cholecystokinin in fertilization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 86 citations in OpenAlex.
- Cholecystokinin: Clinical aspects of the new biology.Journal of internal medicine · 2025Review
- Cholecystokinin and Panic Disorder: Reflections on the History and Some Unsolved Questions.Molecules (Basel, Switzerland) · 2021Review
- Cholecystokinin and the hormone concept.Endocrine connections · 2021Review
- Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes.Frontiers in endocrinology · 2020Review
- Influence of a Virgin Olive Oil versus Butter Plus Cholesterol-Enriched Diet on Testicular Enzymatic Activities in Adult Male Rats.International journal of molecular sciences · 2017Article
- Cholecystokinin-From Local Gut Hormone to Ubiquitous Messenger.Frontiers in endocrinology · 2017Review
- Molecular characterization of cholecystokinin in grass carp (Ctenopharyngodon idellus): cloning, localization, developmental profile, and effect of fasting and refeeding on expression in the brain and intestine.Fish physiology and biochemistry · 2012Article
- The endoproteolytic maturation of progastrin and procholecystokinin.Journal of molecular medicine (Berlin, Germany) · 2006Review
- Cleavage of arginyl-arginine and lysyl-arginine from the C-terminus of pro-hormone peptides by human germinal angiotensin I-converting enzyme (ACE) and the C-domain of human somatic ACE.The Biochemical journal · 1997Article
- Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Proenkephalin products are stored in the sperm acrosome and may function in fertilization.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells.Molecular and cellular biology · 1990Article
- Expression and localization of gastrin messenger RNA and peptide in spermatogenic cells.The Journal of clinical investigation · 1990Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of the gene encoding the neurotransmitter/neuromodulator cholecystokinin (CCK) was demonstrated in testis of several different species. Two testicular CCK mRNA transcripts of different sizes were detected, and studies on the ontogeny of CCK gene expression indicated that the gene was expressed in male germ cells. In situ hybridization revealed CCK mRNA-expressing cells in the peripheral parts of the seminiferous tubules. Biochemical identification showed that the majority of prepro-CCK products in the testis represented pro-CCK. Immunofluorescence studies revealed CCK-like peptides primarily in spermatocytes and spermatids of mouse, rat, and monkey. Immuno electron microscopy of monkey testis demonstrated CCK immunoreactivity in the acrosomal granule of spermatids. Hence, an interesting possibility is that CCK peptides can be released during the acrosome reaction and thus may be of importance in the fertilization process.
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