Evidence map›Paper›PMID 26689523›Full record

ArticleInternational braz j urol : official journal of the Brazilian Society of Urology

Safety and efficacy of low intensity shockwave (LISW) treatment in patients with erectile dysfunction.

A Ruffo, M Capece, D Prezioso, G Romeo, E Illiano, L Romis, G Di Lauro, F Iacono

Registry-linked trialAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06600893 (A Single-Blind, Sham-Controlled, Randomized, Prospective Study Characterizing Erectile Tissue Ultrasound Changes Resulting From Low Intensity Penile Shockwave Treatment With Urogold 100™), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06600893 nacompletednot on this map

A Single-Blind, Sham-Controlled, Randomized, Prospective Study Characterizing Erectile Tissue Ultrasound Changes Resulting From Low Intensity Penile Shockwave Treatment With Urogold 100™

TypeinterventionalSponsorSan Diego Sexual MedicineRan2019 to 2023Enrolled35ConditionsErectile DysfunctionsArmsLow intensity shockwave therapy (LiSWT), Sham
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A RuffoDepartment of Urology, Federico II University, Naples, Italy.
M CapeceDepartment of Urology, Federico II University, Naples, Italy.
D PreziosoDepartment of Urology, Federico II University, Naples, Italy.
G RomeoDepartment of Urology, Federico II University, Naples, Italy.
E IllianoDepartment of Urology, Federico II University, Naples, Italy.
L RomisDepartment of Urology, Hospital Santa Maria delle Grazie, Naples, Italy.
G Di LauroDepartment of Urology, Hospital Santa Maria delle Grazie, Naples, Italy.
F IaconoDepartment of Urology, Federico II University, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe primary goal in the management strategy of a patient with ED would be to determine its etiology and cure it when possible, and not just to treat the symptoms alone. One of the new therapeutic strategies is the use of low intensity extracorporeal shockwave (LISW) therapy. The mechanism of shockwave therapy is not completely clear. It is suggested that LISW induces neovascularization and improvement of cavernosal arterial flow which can lead to an improvement of erectile function by releasing NO, VEGF and PCNA. MATERIALS AND

methods31 patients between February and June 2013 with mild to severe ED and non-Phosphodiesterase 5 inhibitors responders were enrolled. Patients underwent four weekly treatment sessions. During each session 3600 shocks at 0.09mJ/ mm2 were given, 900 shocks at each anatomical area (right and left corpus cavernosum, right and left crus). Improvement of the erectile function was evaluated using the International Index of Erectile Function (IIEF-EF), the Sexual Encounter Profile (SEP) diaries (SEP-Questions 2 and 3) and Global Assessment Questions (GAQ-Q1 and GAQ-Q2).

resultsAt 3-month follow-up IIEF-EF scores improved from 16.54±6.35 at baseline to 21.03±6.38. Patients answering 'yes' to the SEP-Q2 elevated from 61% to 89% and from 32% to 62% in the SEP-Q3. A statistically significant improvement was reported to the Global Assessment Questions (GAQ-Q1 and GAQ-Q2).

conclusionIn conclusion, we can affirm that LISW is a confirmed therapeutic approach to erectile dysfunction that definitely needs more long-term trials to be clarified and further verified.

Indexed as

AgedErectile DysfunctionFollow-Up StudiesHumansLithotripsyMaleMiddle AgedNeovascularization, PhysiologicNitric Oxide SynthasePatient SatisfactionPenile ErectionProliferating Cell Nuclear AntigenReproducibility of ResultsSelf ReportSeverity of Illness IndexTime FactorsNitric Oxide SynthaseProliferating Cell Nuclear AntigenVascular Endothelial Growth Factor A

Identifiers

PMID26689523
PMCPMC4756974

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.