ArticleBioconjugate chemistry2016
Cell-Permeable Esterase-Activated Ca(II)-Sensitive MRI Contrast Agent.
Article in Bioconjugate chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sinapic Acid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents That Target Transforming Growth Factor β‑Activated Kinase 1 (TAK1).ACS pharmacology & translational science · 2025Article
- Nonsteroidal Anti-Inflammatory Drug Conjugated with Gadolinium (III) Complex as an Anti-Inflammatory MRI Agent.International journal of molecular sciences · 2023Article
- Flavonoid-Conjugated Gadolinium Complexes as Anti-Inflammatory Theranostic Agents.Antioxidants (Basel, Switzerland) · 2022Article
- Origins of CaBiochemistry · 2021Article
- Article
- Calcium-responsive contrast agents for functional magnetic resonance imaging.Chemical physics reviews · 2021Review
- Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging.Antioxidants (Basel, Switzerland) · 2020Article
- Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging.Inorganic chemistry · 2020Review
- Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging.Journal of the American Chemical Society · 2019Article
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes.Bioconjugate chemistry · 2018Article
- Effect of Magnetic Coupling on Water Proton Relaxivity in a Series of Transition Metal GdInorganic chemistry · 2018Article
- A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging.Acta pharmaceutica Sinica. B · 2018Article
- Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors.ACS central science · 2017Article
- Membrane-Permeable Mn(III) Complexes for Molecular Magnetic Resonance Imaging of Intracellular Targets.Journal of the American Chemical Society · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
Calcium [Ca(II)] is a fundamental transducer of electrical activity in the central nervous system (CNS). Influx of Ca(II) into the cytosol is responsible for action potential initiation and propagation, and initiates interneuronal communication via release of neurotransmitters and activation of gene expression. Despite the importance of Ca(II) in physiology, it remains a challenge to visualize Ca(II) flux in the central nervous system (CNS) in vivo. To address these challenges, we have developed a new generation, Ca(II)-activated MRI contrast agent that utilizes ethyl esters to increase cell labeling and prevent extracellular divalent Ca(II) binding. Following labeling, the ethyl esters can be cleaved, thus allowing the agent to bind Ca(II), increasing relaxivity and resulting in enhanced positive MR image contrast. The ability of this probe to discriminate between extra- and intracellular Ca(II) may allow for spatiotemporal in vivo imaging of Ca(II) flux during seizures or ischemia where large Ca(II) fluxes (1-10 μM) can result in cell death.
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