ArticleThe International journal of artificial organs2015
Fluid dynamic characterization of a polymeric heart valve prototype (Poli-Valve) tested under continuous and pulsatile flow conditions.
Article in The International journal of artificial organs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Evaluation of the Haemodynamic Behaviour of Stenosed Aortic Heart Valves Using Fluid Structure Interaction Modelling.International journal for numerical methods in biomedical engineering · 2026Article
- Engineering Efforts to Refine Compatibility and Duration of Aortic Valve Replacements: An Overview of Previous Expectations and New Promises.Frontiers in cardiovascular medicine · 2022Review
- Three-dimensional printing for cardiovascular diseases: from anatomical modeling to dynamic functionality.Biomedical engineering online · 2020Review
- An Insight into the Structural Diversity and Clinical Applicability of Polyurethanes in Biomedicine.Polymers · 2020Review
- Mechanical considerations for polymeric heart valve development: Biomechanics, materials, design and manufacturing.Biomaterials · 2019Review
- Design, Analysis and Testing of a Novel Mitral Valve for Transcatheter Implantation.Annals of biomedical engineering · 2017Article
- Evaluation of an aortic valve prosthesis: Fluid-structure interaction or structural simulation?Journal of biomechanics · 2017Article
- A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis.Journal of biomechanical engineering · 2016Article
- Hemocompatibility of styrenic block copolymers for use in prosthetic heart valves.Journal of materials science. Materials in medicine · 2016Article
- A Newly Developed Tri-Leaflet Polymeric Heart Valve Prosthesis.Journal of mechanics in medicine and biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeOnly mechanical and biological heart valve prostheses are currently commercially available. The former show longer durability but require anticoagulant therapy; the latter display better fluid dynamic behavior but do not have adequate durability. New Polymeric Heart Valves (PHVs) could potentially combine the hemodynamic properties of biological valves with the durability of mechanical valves. This work presents a hydrodynamic evaluation of 2 groups of newly developed supra-annular, trileaflet prosthetic heart valves made from styrenic block copolymers (SBC): Poli-Valves.
methods2 types of Poli-Valves made of SBC and differing in polystyrene fraction content were tested under continuous and pulsatile flow conditions as prescribed by ISO 5840 Standard. A pulse duplicator designed ad hoc allowed the valve prototypes to be tested at different flow rates and frequencies. Pressure and flow were recorded; pressure drops, effective orifice area (EOA), and regurgitant volume were computed to assess the behavior of the valve.
resultsBoth types of Poli-Valves met the minimum requirements in terms of regurgitation and EOA as specified by the ISO 5840 Standard. Results were compared with 5 mechanical heart valves (MHVs) and 5 tissue heart valves (THVs), currently available on the market.
conclusionsBased on these results, PHVs based on styrenic block copolymers, as are Poli-Valves, can be considered a promising alternative for heart valve replacement in the near future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.