ArticleThe British journal of radiology2016
Individually tailored contrast enhancement in CT pulmonary angiography.
Article in The British journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03292354 (Personalization of CM Injection Protocols in Coronary Computed Tomographic Angiography), which is not on this map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalization of CM Injection Protocols in Coronary Computed Tomographic Angiography
Who cites it
15 citing papers in PubMed.
- A randomised controlled trial comparing three clinical administration strategies in spectral detector CT pulmonary angiography with low contrast medium dose.European radiology · 2025Trial
- Halved contrast medium dose in lower limb dual-energy computed tomography angiography-a randomized controlled trial.European radiology · 2023Trial
- Application of 50-keV virtual monochromatic imaging combined with a personalized contrast agent protocol in computed tomography pulmonary angiography: a randomized controlled trial.Quantitative imaging in medicine and surgery · 2026Article
- Computed tomography pulmonary angiography in around-the-clock clinical care with individualised scan protocols: a 5-year observational study on incidence and causes of repeat scanning.European radiology · 2026Observational
- Reducing contrast media dosage for pulmonary embolism CTPA in PCD-CT: a comparative study of EID-CT and PCD-CT in the era of individualized protocolling.European radiology · 2026Article
- The impact of body compositions on contrast medium enhancement in chest CT: a randomised controlled trial.BJR open · 2023Article
- An audit of the adequacy of contrast enhancement in CT pulmonary angiograms in a South African tertiary academic hospital setting.SA journal of radiology · 2022Article
- Serial markers of coagulation and inflammation and the occurrence of clinical pulmonary thromboembolism in mechanically ventilated patients with SARS-CoV-2 infection; the prospective Maastricht intensive care COVID cohort.Thrombosis journal · 2021Article
- Towards Personalised Contrast Injection: Artificial-Intelligence-Derived Body Composition and Liver Enhancement in Computed Tomography.Journal of personalized medicine · 2021Article
- CT angiography for pulmonary embolism in the emergency department: investigation of a protocol by 20 ml of high-concentration contrast medium.La Radiologia medica · 2020Article
- Dual energy computed tomography analysis in cancer patients: What factors affect iodine concentration in contrast enhanced studies?European journal of radiology · 2019Article
- Computed Tomography Pulmonary Angiography during Pregnancy: Radiation Dose of Commonly Used Protocols and the Effect of Scan Length Optimization.Korean journal of radiology · 2019Article
- A new dataset of computed-tomography angiography images for computer-aided detection of pulmonary embolism.Scientific data · 2018Article
- Dual Energy CT Pulmonary Angiography with 6g Iodine-A Propensity Score-Matched Study.PloS one · 2016Article
- Tailoring protocols for chest CT applications: when and how?Diagnostic and interventional radiology (Ankara, Turkey)Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose was to evaluate individually shaped contrast media (CM) delivery in CT pulmonary angiography (CTPA) for suspected pulmonary embolism (PE).
methods100 consecutive emergency patients with clinical suspicion of PE were evaluated. High-pitch CTPA was performed on a second-generation dual-source CT using the following parameters: 100 kV, 200-250 mAsref, rotation time 0.28 s, 128 × 0.6 mm col. and image reconstruction 1.0/0.8 mm (B30f). Group 1 (n = 50) then received a fixed CM bolus (300 = mgI ml(-1), volume = 90 ml and flow rate = 6 ml s(-1)); Group 2 (n = 50) received a body weight-adapted CM bolus determined by dedicated contrast injection software. For analysis, groups were further subdivided into low-weight (40-75 kg) and high-weight (76-117 kg) groups. Technical image quality was graded using a four-point Likert scale (1 = non-diagnostic; 2 = diagnostic; 3 = good and 4 = excellent image quality) at the level of the pulmonary trunk and pulmonary arteries. Objective image quality analysis was performed by measuring contrast enhancement in Hounsfield units (HU) at the same levels. Attenuation levels > 180 HU were considered diagnostic.
resultsAll examinations were graded as diagnostic at each level. The individual minimum pulmonary attenuation was 184 and 270 HU for Group 1 and 2, respectively. Mean attenuation was as follows: Group 1: 475 ± 105 HU (40-75 kg) and 402 ± 115 HU (76-117 kg), p < 0.03. Group 2: 424 ± 76 HU (40-75 kg) and 418 ± 100 HU (76-117 kg), p = 0.8. For Group 2, CM volumes were: 55 ± 5 ml (40-75 kg) and 66 ± 5 ml (76-117 kg), leading to 16-51% CM reduction.
conclusionEven under emergency conditions, individualized CM protocols can provide diagnostic and robust image quality in CTPA for PE with a substantial reduction of CM volume for lower weight patients, compared with a fixed CM protocol. ADVANCES IN KNOWLEDGE: CM volume can substantially be reduced by using individualized CM protocols in CT angiography for PE without compromising the diagnostic image quality.
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