Evidence map›Paper›PMID 26688871›Full record

ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2015

Update on Breast Cancer Detection Using Comb-Push Ultrasound Shear Elastography.

Max Denis, Mahdi Bayat, Mohammad Mehrmohammadi, Adriana Gregory, Pengfei Song, Dana H Whaley, Sandhya Pruthi, Shigao Chen, Mostafa Fatemi, Azra Alizad

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05068999 (Early Assessment of Shear Wave Elastography Parameters to Assess the Response to Neoadjuvant Chemotherapy in Patients With Invasive Breast Cancer), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05068999 unknown statusnot on this mapstarted 2021, after this paper: background citation

Early Assessment of Shear Wave Elastography Parameters to Assess the Response to Neoadjuvant Chemotherapy in Patients With Invasive Breast Cancer

TypeobservationalSponsorAssiut UniversityRan2021 to 2023Enrolled35ConditionsBreast NeoplasmsArmsshear wave elastography
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Ultrasound elastography evaluation of age-related muscle atrophy: AnProceedings of meetings on acoustics. Acoustical Society of America · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Evaluation of Reconstruction Parameters for 2-D Comb-Push Ultrasound Shear Wave Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Max Denis
Mahdi Bayat
Mohammad Mehrmohammadi
Adriana Gregory
Pengfei Song
Dana H Whaley
Sandhya Pruthi
Shigao Chen
Mostafa Fatemi
Azra Alizad
Mayo Clinic · USWayne State University · US

Funding

Classification of breast masses based on visco-elastic propertiesR01CA168575 · NCI · MAYO CLINIC ROCHESTER · PI FATEMI, MOSTAFA, INSANA, MICHAEL F · 2013 to 2018
$2.5M
Combined Acoustic Imaging and Viscoelastic Parameters Estimation in Breast CancerR01CA148994 · NCI · MAYO CLINIC ROCHESTER · PI ALIZAD, AZRA · 2011 to 2015
$2.4M
Viscoelastic Parameters estimation and imaging for Thyroid Nodule differentiationR01EB017213 · NIBIB · MAYO CLINIC ROCHESTER · PI ALIZAD, AZRA, CHEN, SHIGAO · 2014 to 2017
$2.2M
Generalized waveform methods for breast viscoelasticity mappingR01CA174723 · NCI · MAYO CLINIC ROCHESTER · PI FATEMI, MOSTAFA · 2014 to 2018
$1.8M
NCI NIH HHS R01 CA148994NCI NIH HHS R01CA148994NCI NIH HHS R01CA148994-S1NCI NIH HHS R01 CA168575NCI NIH HHS R01CA168575NCI NIH HHS R01 CA174723NCI NIH HHS R01CA174723NIBIB NIH HHS R01 EB017213NIBIB NIH HHS R01EB17213
6 · The paper itself

Abstract

In this work, tissue stiffness estimates are used to differentiate between benign and malignant breast masses in a group of pre-biopsy patients. The rationale is that breast masses are often stiffer than healthy tissue; furthermore, malignant masses are stiffer than benign masses. The comb-push ultrasound shear elastography (CUSE) method is used to noninvasively assess a tissue's mechanical properties. CUSE utilizes a sequence of simultaneous multiple laterally spaced acoustic radiation force (ARF) excitations and detection to reconstruct the region of interest (ROI) shear wave speed map, from which a tissue stiffness property can be quantified. In this study, the tissue stiffnesses of 73 breast masses were interrogated. The mean shear wave speeds for benign masses (3.42 ± 1.32 m/s) were lower than malignant breast masses (6.04 ± 1.25 m/s). These speed values correspond to higher stiffness in malignant breast masses (114.9 ± 40.6 kPa) than benign masses (39.4 ± 28.1 kPa and p <; 0.001), when tissue elasticity is quantified by Young's modulus. A Young's modulus >83 kPa is established as a cut-off value for differentiating between malignant and benign suspicious breast masses, with a receiver operating characteristic curve (ROC) of 89.19% sensitivity, 88.69% specificity, and 0.911 for the area under the curve (AUC).

Indexed as

Breast NeoplasmsElasticity Imaging TechniquesFemaleHumansImage Interpretation, Computer-AssistedROC Curve

Identifiers

PMID26688871
PMCPMC4687021
OpenAlexW1618289169

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.