ArticleBMJ open diabetes research & care2015
High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects: Mikkabi cohort study.
Article in BMJ open diabetes research & care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Dietary Intake and Circulating Concentrations of Carotenoids and Risk of Type 2 Diabetes: A Dose-Response Meta-Analysis of Prospective Observational Studies.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Trial
- Therapeutic Modulation of Inflammatory Signaling via Physalis Peruviana-Derived Exosomes: A Targeted Effect on IKK/NFκB/STAT1.Molecular nutrition & food research · 2026Article
- The associations of plasma carotenoids andThe British journal of nutrition · 2026Article
- Persimmon carotenoid extract rich in β-cryptoxanthin improves glucose homeostasis and reduces liver damage in high-fat-diet-induced type 2 diabetic and metabolic dysfunction-associated steatotic liver disease mice.Journal of the science of food and agriculture · 2026Article
- Functional and Therapeutic Roles of Plant-Derived Antioxidants in Type 2 Diabetes Mellitus: Mechanisms, Challenges, and Considerations for Special Populations.Antioxidants (Basel, Switzerland) · 2025Review
- Association Between Lycopene and Metabolic Disease Risk and Mortality: Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus.Nutrients · 2025Review
- An overview of the nutritional quality and health benefits linked to the world diversity of citrus fruits/juices.Journal of food science · 2025Review
- Application of Integrated Optical Density in Evaluating Insulin Expression in the Endocrine Pancreas During Chronic Ethanol Exposure and β-Carotene Supplementation: A Novel Approach Utilizing Artificial Intelligence.Pharmaceuticals (Basel, Switzerland) · 2024Article
- β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.Frontiers in pharmacology · 2024Article
- Impact of serum carotenoids on cardiovascular mortality risk in middle-aged and elderly adults with metabolic syndrome.Frontiers in nutrition · 2024Article
- Some novel bioactivities ofSaudi journal of biological sciences · 2023Article
- Dietary antioxidants and liver enzymes in Rafsanjan, a Region in Southeast Iran.Scientific reports · 2023Article
- Review
- Review
- Carotenoids and Their Health Benefits as Derived via Their Interactions with Gut Microbiota.Advances in nutrition (Bethesda, Md.) · 2023Review
- Neoxanthin is undetectable in human blood after ingestion of fresh young spinach leaf.PloS one · 2023Article
- Optimization and multiple in vitro activity potentials of carotenoids from marine Kocuria sp. RAM1.Scientific reports · 2022Article
- The landscape of potential health benefits of carotenoids as natural supportive therapeutics in protecting against Coronavirus infection.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent epidemiological studies show the association of antioxidant carotenoids with type 2 diabetes, but thorough longitudinal cohort studies regarding this association have not been well conducted. The objective of this study was to investigate longitudinally whether serum carotenoids are associated with the risk for developing type 2 diabetes among Japanese subjects. RESEARCH DESIGN AND
methodsWe conducted a follow-up study on 1073 males and females aged 30-79 years at the baseline from the Mikkabi prospective cohort study. Those who participated in the baseline and completed follow-up surveys were examined longitudinally. Over the 10-year period, 910 subjects (295 males and 615 females) took part in the follow-up survey at least one time. A cohort of 264 males and 600 females free of diabetes at baseline was studied.
resultsOver a mean follow-up period of 7.8 years (SD=2.9), 22 males and 33 females developed new type 2 diabetes. After adjustments for confounders, the HRs for type 2 diabetes in the highest tertiles of serum α-carotene, β-cryptoxanthin, and total provitamin A carotenoids against the lowest tertiles were 0.35 (95% CI 0.15 to 0.82), 0.43 (CI 0.20 to 0.92) and 0.41 (CI 0.19 to 0.90), respectively. For β-carotene and zeaxanthin, borderline reduced risks were also observed, but these were not significant.
conclusionsOur results further support the hypothesis that eating a diet rich in carotenoids, especially provitamin A carotenoids, might help prevent the development of type 2 diabetes in Japanese patients. TRIAL REGISTRATION NUMBER: NIFT-2013001.
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