Evidence map›Paper›PMID 26688695›Full record

ArticleJournal of drug delivery science and technology2015

Hybrid responsive hydrogel carriers for oral delivery of low molecular weight therapeutic agents.

M Caldorera-Moore, K Maass, R Hegab, G Fletcher, N Peppas

Abstract read
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In one paragraph

Article in Journal of drug delivery science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M Caldorera-MooreDepartment of Biomedical Engineering, Louisiana Tech University, Ruston, LA 71272, USA ; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA ; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
K MaassDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
R HegabDepartment of Biomedical Engineering, Louisiana Tech University, Ruston, LA 71272, USA.
G FletcherDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
N PeppasDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA ; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA ; Division of Pharmaceutics, The University of Texas at Austin, Austin, TX 78712, USA ; Institute for Biomaterials, Drug Delivery and Regenerative Medicine, The University of Texas at Austin, Austin, TX 78712, USA.

Funding

pH Sensitive Complex Hydrogels for Protein Drug ReleaseR01EB000246 · NIBIB · UNIVERSITY OF TEXAS AUSTIN · PI LOWMAN, ANTHONY M, PEPPAS, NICHOLAS A · 2002 to 2014
$3.8M
NIBIB NIH HHS R01 EB000246
6 · The paper itself

Abstract

Hydrogels have been influential in the development of controlled release systems for a wide variety of therapeutic agents. These materials are attractive as carriers for transmucosal and intracellular drug delivery because of their inherent biocompatibility, tunable physicochemical properties, basic synthesis, and ability to be physiologically responsive. Due to their hydrophilic nature, hydrogel-based carrier systems are not always the best systems for delivery of small molecular weight, hydrophobic therapeutic agents. In this work, versatile hydrogel-based carriers composed of copolymers of methyl methacrylate (MMA) and acrylic acid (AA) were designed and synthesized to create formulations for oral delivery of small molecular weight therapeutic agents. Through practical material selection and careful design of copolymer composition and molecular architecture, we engineered systems capable of responding to physiological changes, with tunable physicochemical properties that are optimized to load, protect, and deliver their payloads to their intended site of action. The synthesized carriers' ability to respond to changes in pH, to load and release small molecular weight drugs, and biocompatibility were investigated. Our results suggest these hydrophilic networks have great potential for controlled delivery of small-molecular weight, hydrophobic and hydrophilic agents.

Indexed as

Oral deliverypH responsive deliveryPoly(acrylic acid)Poly(methacrylic acid)Responsive hydrogels

Identifiers

PMID26688695
PMCPMC4680998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.