Evidence map›Paper›PMID 26688591›Full record

ArticleCoordination chemistry reviews2016

Biological signaling by small inorganic molecules.

Debashree Basudhar, Lisa A Ridnour, Robert Cheng, Aparna H Kesarwala, Julie Heinecke, David A Wink

Open access · greenAbstract read
In one paragraph

Article in Coordination chemistry reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 92 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies.Frontiers in cellular and infection microbiology · 2025
    Review
  5. Article
  6. Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for HAngewandte Chemie (International ed. in English) · 2024
    Article
  7. Review
  8. Unraveling Metal-Ligand Bonding in an HNO-Evolving {FeNO}Journal of the American Chemical Society · 2023
    Article
  9. Article
  10. Review
  11. Methods in sulfide and persulfide research.Nitric oxide : biology and chemistry · 2021
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Desiccation Tolerance as the Basis of Long-Term Seed Viability.International journal of molecular sciences · 2020
    Review
  17. Review
  18. Article
  19. Review
  20. Mechanisms of HNO Reactions with Ferric Heme Proteins.Angewandte Chemie (International ed. in English) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Debashree BasudharRadiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
Lisa A RidnourRadiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
Robert ChengRadiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
Aparna H KesarwalaRadiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
Julie HeineckeRadiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
David A WinkRadiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892.
National Cancer Institute · US

Funding

Nitric Oxide as a Modifier of Oxidative StressZIASC007281 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI WINK, DAVID · 2009 to 2025
$8.1M
NITRIC OXIDE AS A MODIFIER OF OXIDATIVE STRESSZ01SC007281 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI WINK, DAVID A · 1996 to 2008
$1.8M
Intramural NIH HHS Z01 SC007281
6 · The paper itself

Abstract

Small redox active molecules such as reactive nitrogen and oxygen species and hydrogen sulfide have emerged as important biological mediators that are involved in various physiological and pathophysiological processes. Advancement in understanding of cellular mechanisms that tightly regulate both generation and reactivity of these molecules is central to improved management of various disease states including cancer and cardiovascular dysfunction. Imbalance in the production of redox active molecules can lead to damage of critical cellular components such as cell membranes, proteins and DNA and thus may trigger the onset of disease. These small inorganic molecules react independently as well as in a concerted manner to mediate physiological responses. This review provides a general overview of the redox biology of these key molecules, their diverse chemistry relevant to physiological processes and their interrelated nature in cellular signaling.

Identifiers

PMID26688591
PMCPMC4680994
OpenAlexW2191665487

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.