SynthesisFertility and sterility2016
Effectiveness of semen washing to prevent human immunodeficiency virus (HIV) transmission and assist pregnancy in HIV-discordant couples: a systematic review and meta-analysis.
Synthesis in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Is the outpatient management of acute diverticulitis safe and effective? A systematic review and meta-analysis.Techniques in coloproctology · 2019Pooled it
- A Systematic Review of the Current Status of Safer Conception Strategies for HIV Affected Heterosexual Couples in Sub-Saharan Africa.AIDS and behavior · 2018Pooled it
- The efficacy and toxicity profile of metronomic chemotherapy for metastatic breast cancer: A meta-analysis.PloS one · 2017Pooled it
- Indications for Micro-Injection of Sperm in Assisted Reproduction: A Consensus Statement.The Australian & New Zealand journal of obstetrics & gynaecology · 2026Article
- Article
- GRADE Use in Evidence Syntheses Published in High-Impact-Factor Gynecology and Obstetrics Journals: A Methodological Survey.Journal of clinical medicine · 2023Article
- Preventing HIV and achieving pregnancy among HIV sero-different couples: Pilot study of a safer conception intervention in Zimbabwe.PLOS global public health · 2023Article
- Intra Uterine Insemination in Two Couples with HPV Detection by Hyaluronidase-Based Swim-up Washing: Cases Report.Journal of personalized medicine · 2022Article
- Validation of a SARS-CoV-2 RT-PCR assay: a requirement to evaluate viral contamination in human semen.Reproductive biomedicine online · 2022Article
- Article
- Human seminal virome: a panel based on recent literature.Basic and clinical andrology · 2022Review
- Epigenetic Alterations in Cryopreserved Human Spermatozoa: Suspected Potential Functional Defects.Cells · 2022Article
- Sexual and Relationship Benefits of a Safer Conception Intervention Among Men with HIV Who Seek to Have Children with Serodifferent Partners in Uganda.AIDS and behavior · 2022Article
- The Public Perception of the #GeneEditedBabies Event Across Multiple Social Media Platforms: Observational Study.Journal of medical Internet research · 2022Observational
- Can We Cryopreserve the Sperm of COVID-19 Patients During the Pandemic?Frontiers in endocrinology · 2022Review
- Addressing Conflicts of Interest and Conflicts of Commitment in Public Advocacy and Policy Making on CRISPR/Cas-Based Human Genome Editing.Frontiers in research metrics and analytics · 2022Article
- Article
- Impaired semen parameters in patients with confirmed SARS-CoV-2 infection: A prospective cohort study.Andrologia · 2021Article
- Article
- Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo evaluate the effectiveness of semen washing in human immunodeficiency virus (HIV)-discordant couples in which the male partner is infected.
designSystematic review and meta-analysis.
settingNot applicable. PATIENT(S): Forty single-arm open-label studies among HIV-discordant couples that underwent intrauterine insemination (IUI) or in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) using washed semen. INTERVENTION(S): Semen washing followed by IUI, IVF, or IVF/ICSI. MAIN OUTCOME MEASURE(S): PRIMARY OUTCOME: HIV transmission to HIV-uninfected women; secondary outcomes: HIV transmission to newborns and proportion of couples achieving a clinical pregnancy. RESULT(S): No HIV transmission occurred in 11,585 cycles of assisted reproduction with the use of washed semen among 3,994 women. Among the subset of HIV-infected men without plasma viral suppression at the time of semen washing, no HIV seroconversions occurred among 1,023 women after 2,863 cycles of assisted reproduction with the use of washed semen. Studies that measured HIV transmission to infants reported no cases of vertical transmission. Overall, 56.3% of couples (2,357/4,184) achieved a clinical pregnancy with the use of washed semen. CONCLUSION(S): Semen washing appears to significantly reduce the risk of transmission in HIV-discordant couples desiring children, regardless of viral suppression in the male partner. There are no randomized controlled studies or studies from low-income countries, especially those with a large burden of HIV. Continued development of lower-cost semen washing and assisted reproduction technologies is needed. Integration of semen washing into HIV prevention interventions could help to further reduce the spread of HIV.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.