ArticleFungal genetics and biology : FG & B2016
Horizontal acquisition of toxic alkaloid synthesis in a clade of plant associated fungi.
Article in Fungal genetics and biology : FG & B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
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- Endophyte genomes support greater metabolic gene cluster diversity compared with non-endophytes in Trichoderma.PloS one · 2023Article
- Fungal evolution: cellular, genomic and metabolic complexity.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Patterns and impacts of nonvertical evolution in eukaryotes: a paradigm shift.Annals of the New York Academy of Sciences · 2020Review
- New insights into the evolution of host specificity of threeVirulence · 2020Article
- A Small Horizontally Transferred Gene Cluster Contributes to the Sporulation of Alternaria alternata.Genome biology and evolution · 2019Article
- Evolutionary and functional patterns of shared gene neighbourhood in fungi.Nature microbiology · 2019Article
- Multilayered horizontal operon transfers from bacteria reconstruct a thiamine salvage pathway in yeasts.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- The MSDIN family in amanitin-producing mushrooms and evolution of the prolyl oligopeptidase genes.IMA fungus · 2018Article
- Six Key Traits of Fungi: Their Evolutionary Origins and Genetic Bases.Microbiology spectrum · 2017Article
- Ergot Alkaloids of the Family Clavicipitaceae.Phytopathology · 2017Review
- Non-Thyroidal Illness Syndrome in Patients Exposed to Indoor Air Dampness Microbiota Treated Successfully with Triiodothyronine.Frontiers in immunology · 2017Article
- Secondary metabolite gene clusters in the entomopathogen fungus Metarhizium anisopliae: genome identification and patterns of expression in a cuticle infection model.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Clavicipitaceae is a fungal group that comprises species that closely interact with plants as pathogens, parasites or symbionts. A key factor in these interactions is the ability of these fungi to synthesize toxic alkaloid compounds that contribute to the protection of the plant host against herbivores. Some of these compounds such as ergot alkaloids are toxic to humans and have caused important epidemics throughout history. The gene clusters encoding the proteins responsible for the synthesis of ergot alkaloids and lolines in Clavicipitaceae have been elucidated. Notably, homologs to these gene clusters can be found in distantly related species such as Aspergillus fumigatus and Penicillium expansum, which diverged from Clavicipitaceae more than 400 million years ago. We here use a phylogenetic approach to analyze the evolution of these gene clusters. We found that the gene clusters conferring the ability to synthesize ergot alkaloids and loline emerged first in Eurotiomycetes and were then likely transferred horizontally to Clavicipitaceae. Horizontal gene transfer is known to play a role in shaping the distribution of secondary metabolism clusters across distantly related fungal species. We propose that HGT events have played an important role in the capability of Clavicipitaceae to produce two key secondary metabolites that have enhanced the ability of these species to protect their plant hosts, therefore favoring their interactions.
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