ArticleScientific reports2015
Ultrasound-aided Multi-parametric Photoacoustic Microscopy of the Mouse Brain.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 99 citations in OpenAlex.
- Multi-parametric longitudinal imaging of cerebral biomarkers in a rodent model of Alzheimer's disease.Photoacoustics · 2026Article
- Advances in photoacoustic imaging reconstruction and quantitative analysis for biomedical applications.Visual computing for industry, biomedicine, and art · 2026Review
- Ischemic stroke neuroprotection revisited: translational barriers and a phase-resolved, biomarker-anchored framework.Archives of pharmacal research · 2026Review
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Photoacoustic and fluorescence dual-modality imaging of cerebral biomarkers in Alzheimer's disease rodent model.Journal of biomedical optics · 2024Article
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
- Dual-modal Photoacoustic and Ultrasound Imaging: from preclinical to clinical applications.Frontiers in photonics · 2024Article
- Effects of Acute and Endurance Exercise on Cerebrovascular Function and Oxygen Metabolism: A Photoacoustic Microscopy Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia.Stroke · 2023Review
- Simultaneous dual-modal photoacoustic and harmonic ultrasound microscopy with an optimized acoustic combiner.Biomedical optics express · 2023Article
- Optical-resolution photoacoustic microscopy with a needle-shaped beam.Nature photonics · 2023Article
- Deep Learning-Powered Bessel-Beam Multiparametric Photoacoustic Microscopy.IEEE transactions on medical imaging · 2022Article
- Fully integrated photoacoustic microscopy and photoplethysmography of humanPhotoacoustics · 2022Article
- SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers.Neurobiology of disease · 2022Article
- Photoacoustic microscopy of vascular adaptation and tissue oxygen metabolism during cutaneous wound healing.Biomedical optics express · 2022Article
- Tracking Strain-Specific Morphogenesis and Angiogenesis of Murine Calvaria with Large-Scale Optoacoustic and Ultrasound Microscopy.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Sparse Coding-Enabled Low-Fluence Multi-Parametric Photoacoustic Microscopy.IEEE transactions on medical imaging · 2022Article
- Multi-scale optoacoustic molecular imaging of brain diseases.European journal of nuclear medicine and molecular imaging · 2021Review
- Wavelength and pulse energy optimization for detecting hypoxia in photoacoustic imaging of the neonatal brain: a simulation study.Biomedical optics express · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
High-resolution quantitative imaging of cerebral oxygen metabolism in mice is crucial for understanding brain functions and formulating new strategies to treat neurological disorders, but remains a challenge. Here, we report on our newly developed ultrasound-aided multi-parametric photoacoustic microscopy (PAM), which enables simultaneous quantification of the total concentration of hemoglobin (CHb), the oxygen saturation of hemoglobin (sO2), and cerebral blood flow (CBF) at the microscopic level and through the intact mouse skull. The three-dimensional skull and vascular anatomies delineated by the dual-contrast (i.e., ultrasonic and photoacoustic) system provide important guidance for dynamically focused contour scan and vessel orientation-dependent correction of CBF, respectively. Moreover, bi-directional raster scan allows determining the direction of blood flow in individual vessels. Capable of imaging all three hemodynamic parameters at the same spatiotemporal scale, our ultrasound-aided PAM fills a critical gap in preclinical neuroimaging and lays the foundation for high-resolution mapping of the cerebral metabolic rate of oxygen (CMRO2)-a quantitative index of cerebral oxygen metabolism. This technical innovation is expected to shed new light on the mechanism and treatment of a broad spectrum of neurological disorders, including Alzheimer's disease and ischemic stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.