ArticleScientific reports2015
An ancestral host defence peptide within human β-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Mechanistic Insights into Human Defensin Antimicrobial Activity from Membrane Simulations.The Journal of membrane biology · 2026Article
- The Archetypal Gamma-Core Motif of Antimicrobial Cys-Rich Peptides Inhibits HInternational journal of molecular sciences · 2024Article
- The Antimicrobial Activity of Human Defensins at Physiological Non-Permeabilizing Concentrations Is Caused by the Inhibition of the Plasma Membrane HInternational journal of molecular sciences · 2024Article
- Article
- SARS-CoV-2 Fusion Peptide Conjugated to a Tetravalent Dendrimer Selectively Inhibits Viral Infection.Pharmaceutics · 2023Article
- Insight into the Molecular Signature of Skeletal Muscle Characterizing Lifelong Football Players.International journal of environmental research and public health · 2022Article
- Immune Modulation Ability of Hepcidin from Teleost Fish.Animals : an open access journal from MDPI · 2022Article
- The Challenges of Eradicating PediatricChildren (Basel, Switzerland) · 2022Review
- Antimicrobial Peptides and Their Applications in Biomedical Sector.Antibiotics (Basel, Switzerland) · 2021Review
- Gastric Microenvironment-A Partnership between Innate Immunity and Gastric Microbiota TricksJournal of clinical medicine · 2021Review
- Tick defensin γ-core reduces Fusarium graminearum growth and abrogates mycotoxins production with high efficiency.Scientific reports · 2021Article
- Urinary Biomarkers: Diagnostic Tools for Monitoring Athletes' Health Status.International journal of environmental research and public health · 2020Article
- Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2020Review
- HNP-1 and HBD-1 as Biomarkers for the Immune Systems of Elite Basketball Athletes.Antibiotics (Basel, Switzerland) · 2020Article
- Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells.Molecules (Basel, Switzerland) · 2020Article
- Porcine β-defensin 2 inhibits proliferation of pseudorabies virus in vitro and in transgenic mice.Virology journal · 2020Article
- A Novel View of HumanBiomolecules · 2019Review
- Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity.PloS one · 2019Article
- The Amphibian Antimicrobial Peptide Temporin B InhibitsAntimicrobial agents and chemotherapy · 2018Article
- Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 2 countries.
Funding
Abstract
Host defence peptides (HDPs) are critical components of innate immunity. Despite their diversity, they share common features including a structural signature, designated "γ-core motif". We reasoned that for each HDPs evolved from an ancestral γ-core, the latter should be the evolutionary starting point of the molecule, i.e. it should represent a structural scaffold for the modular construction of the full-length molecule, and possess biological properties. We explored the γ-core of human β-defensin 3 (HBD3) and found that it: (a) is the folding nucleus of HBD3; (b) folds rapidly and is stable in human serum; (c) displays antibacterial activity; (d) binds to CD98, which mediates HBD3 internalization in eukaryotic cells; (e) exerts antiviral activity against human immunodeficiency virus and herpes simplex virus; and (f) is not toxic to human cells. These results demonstrate that the γ-core within HBD3 is the ancestral core of the full-length molecule and is a viable HDP per se, since it is endowed with the most important biological features of HBD3. Notably, the small, stable scaffold of the HBD3 γ-core can be exploited to design disease-specific antimicrobial agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.