ArticleDevelopmental cell2015
Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination.
Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Report on the seventh Japanese meeting on biological function and evolution through interactions between hosts and transposable elements.Mobile DNA · 2026Article
- Identification and characterization of the de novo methyltransferases for eukaryoticScience advances · 2025Article
- The sixth Japanese meeting on biological function and evolution through interactions between hosts and transposable elements.Mobile DNA · 2023Article
- The Conjusome-A Transient Organelle Linking Genome Rearrangements in the Parental and Developing Macronuclei.Microorganisms · 2023Article
- A practical reference for studying meiosis in the model ciliateMarine life science & technology · 2022Review
- Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant.PloS one · 2022Article
- Article
- A Polycomb repressive complex is required for RNAi-mediated heterochromatin formation and dynamic distribution of nuclear bodies.Nucleic acids research · 2021Article
- Spatial constraints on chromosomes are instrumental to meiotic pairing.Journal of cell science · 2020Article
- Programmed genome rearrangements in ciliates.Cellular and molecular life sciences : CMLS · 2020Review
- Roles of Noncoding RNAs in Ciliate Genome Architecture.Journal of molecular biology · 2020Review
- RACS: rapid analysis of ChIP-Seq data for contig based genomes.BMC bioinformatics · 2019Article
- A specialized condensin complex participates in somatic nuclear maturation inMolecular biology of the cell · 2019Article
- RNAi-dependentGenes & development · 2019Article
- Article
- ChIP-ping the branches of the tree: functional genomics and the evolution of eukaryotic gene regulation.Briefings in functional genomics · 2018Review
- Diversification of HP1-like Chromo Domain Proteins in Tetrahymena thermophila.The Journal of eukaryotic microbiology · 2018Article
- Whats, hows and whys of programmed DNA elimination inOpen biology · 2017Review
- A germline-limited piggyBac transposase gene is required for precise excision in Tetrahymena genome rearrangement.Nucleic acids research · 2017Article
- Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena.Cell reports · 2017Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterochromatic loci are often assembled into higher-order heterochromatin bodies in diverse eukaryotes. However, the formation and biological roles of heterochromatin bodies are poorly understood. In the ciliated protozoan Tetrahymena, de novo heterochromatin body formation is accompanied by programmed DNA elimination. Here, we show that the heterochromatin body component Jub1p promotes heterochromatin body formation and dephosphorylation of the Heterochromatin Protein 1-like protein Pdd1p. Through the mutagenesis of the phosphorylated residues of Pdd1p, we demonstrate that Pdd1p dephosphorylation promotes the electrostatic interaction between Pdd1p and RNA in vitro and heterochromatin body formation in vivo. We therefore propose that heterochromatin body is assembled by the Pdd1p-RNA interaction. Pdd1p dephosphorylation and Jub1p are required for heterochromatin body formation and DNA elimination but not for local heterochromatin assembly, indicating that heterochromatin body plays an essential role in DNA elimination.
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