ArticleChemosphere2016
DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status.
Article in Chemosphere, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Exploring cadmium exposure as a contributor to male infertility: insights from the relationship between environmental pollutants and the male reproductive system.Frontiers in endocrinology · 2026Pooled it
- Examining the Relationships Between Blood Cadmium, DNA Methylation Biomarker, Telomere Length, and Their Associations with Mortality in U.S. Adults.Life (Basel, Switzerland) · 2025Article
- Smoke signals in the genome: Epigenetic consequences of parental tobacco exposure (Review).Biomedical reports · 2025Review
- LINE-1 DNA methylation mediates smoking-related risk in site-specific urothelial carcinoma: a Taiwan case-control study.Archives of toxicology · 2025Article
- Cadmium exposure, epigenetic modifications, and serum cystatin C: insights into mediated pathways and mortality risks in U.S. adults.Clinical epigenetics · 2025Article
- Mechanisms of Heavy Metal Cadmium (Cd)-Induced Malignancy.Biological trace element research · 2025Review
- Associations among global long interspersed nuclear element-1 DNA methylation, metal exposure, and chronic kidney disease.Archives of toxicology · 2024Article
- Epigenetics and environmental health.Frontiers of medicine · 2024Review
- Review
- Environmental risk factors of systemic lupus erythematosus: a case-control study.Scientific reports · 2023Article
- Toxicoepigenetics and Environmental Health: Challenges and Opportunities.Chemical research in toxicology · 2022Review
- Urinary heavy metals in residents from a typical city in South China: human exposure and health risks.Environmental science and pollution research international · 2022Article
- Hypomethylation of LINE-1 retrotransposons is associated with cadmium-induced testicular injury.Environmental science and pollution research international · 2020Article
- Smoking-Related DNA Methylation is Differentially Associated with Cadmium Concentration in Blood.Biochemical genetics · 2020Article
- Cadmium, Smoking, and Human Blood DNA Methylation Profiles in Adults from the Strong Heart Study.Environmental health perspectives · 2020Article
- In vitro and bioinformatics mechanistic-based approach for cadmium carcinogenicity understanding.Toxicology in vitro : an international journal published in association with BIBRA · 2020Article
- The impact of environmental cadmium exposure on type 2 diabetes risk: a protocol for an overview of systematic reviews.Systematic reviews · 2019Article
- DNA Methylation and SNPs in VCX are Correlated with Sex Differences in the Response to Chronic Hepatitis B.Virologica Sinica · 2019Article
- Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts.Environmental health perspectives · 2018Article
- DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk and disease heterogeneity.Lupus science & medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
The adverse health effects of cadmium (Cd) are well known in human populations; however, much of what is known about biological mechanisms of Cd comes from in vitro and animal studies. The adverse health outcomes due to high levels of Cd exposure in the population of Mae Sot, Thailand have been extensively characterized. Here, for the first time, this population is being studied in an epigenetic context. The objective of this study was to characterize the association between DNA methylation markers and Cd exposure, taking into account sex and smoking differences, in an adult population at an increased risk of experiencing adverse health outcomes from high body burden of Cd. One hundred and sixty-nine residents from known exposure areas of Mae Sot, Thailand and one hundred residents from non-exposed areas nearby were surveyed in 2012. Urine and blood samples were collected for measurement of urinary Cd (UCd) and DNA methylation of Cd-related markers (DNMT3B, MGMT, LINE-1, MT2A). UCd levels were 7 times higher in the exposed compared to the unexposed populations (exposed median: 7.4 μg/L, unexposed median: 1.0 μg/L, p < 0.001). MGMT hypomethylation was associated with increasing levels of UCd in the total population. Sex-specific associations included MT2A and DNMT3B hypomethylation in women and LINE-1 hypermethylation in men with increasing UCd. Upon subanalysis, these associations separated by smoking status. In summary, environmental Cd exposure is associated with gene-specific DNA methylation in a sex and smoking dependent manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.