Evidence map›Paper›PMID 26688157›Full record

ArticleInternational wound journal2017

Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process.

Christopher Dunnill, Thomas Patton, James Brennan, John Barrett, Matthew Dryden, Jonathan Cooke, David Leaper, Nikolaos T Georgopoulos

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 530 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
530citing papers in PubMed, 3 pooled it
22.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

530 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,266 citations in OpenAlex.

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  4. Pharmaceutical biology · 2026
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470 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Christopher DunnillInstitute of Skin Integrity and Infection Prevention, University of Huddersfield, Huddersfield, UK.
Thomas PattonInstitute of Technology, Sligo, Ireland.
James BrennanInstitute of Technology, Sligo, Ireland.
John BarrettInstitute of Technology, Sligo, Ireland.
Matthew DrydenDepartment of Microbiology, Hampshire Hospitals NHS Foundation Trust, Winchester, UK.
Jonathan CookeCentre for Infection Prevention and Management, Division of Medicine, Imperial College, London, UK.
David LeaperInstitute of Skin Integrity and Infection Prevention, University of Huddersfield, Huddersfield, UK.
Nikolaos T GeorgopoulosInstitute of Skin Integrity and Infection Prevention, University of Huddersfield, Huddersfield, UK.
Institute of Technology Sligo · IEUniversity of Huddersfield · GBHampshire Hospitals NHS Foundation Trust · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) play a pivotal role in the orchestration of the normal wound-healing response. They act as secondary messengers to many immunocytes and non-lymphoid cells, which are involved in the repair process, and appear to be important in coordinating the recruitment of lymphoid cells to the wound site and effective tissue repair. ROS also possess the ability to regulate the formation of blood vessels (angiogenesis) at the wound site and the optimal perfusion of blood into the wound-healing area. ROS act in the host's defence through phagocytes that induce an ROS burst onto the pathogens present in wounds, leading to their destruction, and during this period, excess ROS leakage into the surrounding environment has further bacteriostatic effects. In light of these important roles of ROS in wound healing and the continued quest for therapeutic strategies to treat wounds in general and chronic wounds, such as diabetic foot ulcers, venous and arterial leg ulcers and pressure ulcers in particular, the manipulation of ROS represents a promising avenue for improving wound-healing responses when they are stalled. This article presents a review of the evidence supporting the critical role of ROS in wound healing and infection control at the wound site, and some of the new emerging concepts associated with ROS modulation and its potential in improving wound healing are discussed.

Indexed as

Cell ProliferationHumansReactive Oxygen SpeciesWound HealingWound InfectionWounds and InjuriesReactive Oxygen SpeciesHost defenceReactive oxygen speciesWound healingWound infection

Identifiers

PMID26688157
PMCPMC7950185
OpenAlexW2220643393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.