ArticleCortex; a journal devoted to the study of the nervous system and behavior2016
A 10-month prospective study of organophosphorus pesticide exposure and neurobehavioral performance among adolescents in Egypt.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- A Systematic Review on the Influences of Neurotoxicological Xenobiotic Compounds on Inhibitory Control.Frontiers in behavioral neuroscience · 2019Pooled it
- Psychiatric Risk Implications From Behavioral and Neural Effects of Adolescent Exposure to Environmental Insecticides: A Systematic Review of Rodent Studies.Biological psychiatry · 2026Review
- Effects of Pesticide Exposure on Cognitive Functions in Agricultural Workers: A Systematic Review.Florence Nightingale journal of nursing · 2026Article
- Associations between concurrent neonicotinoid, pyrethroid, and organophosphate insecticide metabolites and neurocognitive performance in Ecuadorian adolescents.The Science of the total environment · 2025Article
- Effects of exposure to insecticides on sleep and neurobehavioural functioning in puberty and adolescence: a scoping review.Arhiv za higijenu rada i toksikologiju · 2025Article
- Review
- Cognitive Impairment and Neurodegenerative Diseases Development Associated with Organophosphate Pesticides Exposure: a Review Study.Neurotoxicity research · 2022Review
- Time after a peak-pesticide use period and neurobehavior among ecuadorian children and adolescents: The ESPINA study.Environmental research · 2022Article
- Reliability of a computer-based neurobehavioral assessment test battery for Bangladeshi adolescent children.Neurotoxicology · 2021Article
- Article
- Evaluation of occupational pesticide exposure on Egyptian male adolescent cognitive and motor functioning.Environmental research · 2021Article
- Associations of acetylcholinesterase inhibition between pesticide spray seasons with depression and anxiety symptoms in adolescents, and the role of sex and adrenal hormones on gender moderation.Exposure and health · 2021Article
- Associations of the Behavioral Assessment and Research System (BARS) neurobehavioral outcomes with attention problems in children living near coal ash storage sites.Neurotoxicology · 2020Article
- Reduced neurobehavioral functioning in agricultural workers and rural inhabitants exposed to pesticides in northern Chile and its association with blood biomarkers inhibition.Environmental health : a global access science source · 2020Article
- Risk perception and behavior in Egyptian adolescent pesticide applicators: an intervention study.BMC public health · 2020Article
- Magnitude of behavioral deficits varies with job-related chlorpyrifos exposure levels among Egyptian pesticide workers.Neurotoxicology · 2020Article
- Residential proximity to greenhouse agriculture and neurobehavioral performance in Ecuadorian children.International journal of hygiene and environmental health · 2020Article
- Occupational pesticide exposure and symptoms of attention deficit hyperactivity disorder in adolescent pesticide applicators in Egypt.Neurotoxicology · 2019Article
- Associations of acetylcholinesterase activity with depression and anxiety symptoms among adolescents growing up near pesticide spray sites.International journal of hygiene and environmental health · 2019Article
- Environmental Health Research in Africa: Important Progress and Promising Opportunities.Frontiers in genetics · 2019Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Chlorpyrifos is an organophosphorus (OP) pesticide widely used around the world for agricultural operations. Although studies have examined exposure in children, there is limited information on adolescents who are occupationally exposed. Furthermore, there is limited research addressing the change in exposure patterns and outcomes across the application season. The goal of the current study was to examine the impact of chlorpyrifos exposure on neurobehavioral performance in adolescents before, during and after the application season. The longitudinal study was conducted in Egypt from April 2010 to January 2011, quantifying exposure and neurobehavioral performance with repeated measures prior to, during, and following the application period. At each test session, participants completed a neurobehavioral test battery and urine was collected for analysis of the chlorpyrifos metabolite 3,5,6-trichloro-2 pyridinol (TCPy) (biomarker of exposure). Cumulative urinary TCPy over the study period was used to classify participants into low (<median) and high (≥ median) exposure groups. The urinary TCPy concentrations increased for both groups during the application season and decreased following the end of application. TCPy levels were significantly elevated in the high exposure group compared to the low exposure groups at all time intervals except baseline. Deficits in cumulative neurobehavioral performance were found among the high exposure group compared with the low exposure group. Additionally, changes in neurobehavioral performance across the application season indicate a pattern of impaired performance in the high exposure group compared to the low exposure group. Deficits increased during the application season and remained even months after application ceased. This study is the first to examine the impact of changes in pesticide exposure and neurobehavioral performance not only before and after the application season, but also within the application season. Furthermore, this study examines the impact of pesticide exposure on an adolescent population who may be at greater risk than adult populations.
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Registered trials
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