ArticleScientific reports2015
Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 8 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- A review of the relationship between dimensions of alcohol consumption and the burden of disease: 2026 update including Mendelian randomisation studies.Addiction (Abingdon, England) · 2026Pooled it
- Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.Nature communications · 2025Pooled it
- A burden of proof study on alcohol consumption and ischemic heart disease.Nature communications · 2024Pooled it
- Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies.Frontiers in epidemiology · 2024Pooled it
- Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies.European journal of epidemiology · 2022Pooled it
- Association of longitudinal alcohol consumption trajectories with coronary heart disease: a meta-analysis of six cohort studies using individual participant data.BMC medicine · 2018Pooled it
- Metabolic profiling of alcohol consumption in 9778 young adults.International journal of epidemiology · 2016Pooled it
- Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization.Scientific reports · 2016Pooled it
- Using Negative Control Outcomes to Detect Selection Bias in Mendelian Randomization Studies.Statistics in medicine · 2026Article
- The Economics and Econometrics of Gene-Environment Interplay.The Review of economic studies · 2026Article
- Patterns and predictors of alcohol misuse trajectories from adolescence through early midlife.Development and psychopathology · 2025Article
- Effects of Sleep-Disordered Breathing on Daytime Brain Activity in Community-Dwelling Older Adults.Sleep science (Sao Paulo, Brazil) · 2025Article
- From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases.Rheumatology and therapy · 2025Review
- Mendelian Randomization Studies: Opening a New Window in the Study of Metabolic Diseases and Chronic Kidney Disease.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Alcohol consumption and allergic diseases: Mendelian randomization evidence from China.Global health action · 2024Article
- Review
- Addressing the credibility crisis in Mendelian randomization.BMC medicine · 2024Review
- Dietary Patterns, Food Intake and Health: New Evidence from Epidemiological and Genetic Studies.Nutrients · 2024Article
- Unravelling the complex causal effects of substance use behaviours on common diseases.Communications medicine · 2024Article
- Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis.Journal of atherosclerosis and thrombosis · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Mendelian randomisation studies from Asia suggest detrimental influences of alcohol on cardiovascular risk factors, but such associations are observed mainly in men. The absence of associations of genetic variants (e.g. rs671 in ALDH2) with such risk factors in women - who drank little in these populations - provides evidence that the observations are not due to genetic pleiotropy. Here, we present a Mendelian randomisation study in a South Korean population (3,365 men and 3,787 women) that 1) provides robust evidence that alcohol consumption adversely affects several cardiovascular disease risk factors, including blood pressure, waist to hip ratio, fasting blood glucose and triglyceride levels. Alcohol also increases HDL cholesterol and lowers LDL cholesterol. Our study also 2) replicates sex differences in associations which suggests pleiotropy does not underlie the associations, 3) provides further evidence that association is not due to pleiotropy by showing null effects in male non-drinkers, and 4) illustrates a way to measure population-level association where alcohol intake is stratified by sex. In conclusion, population-level instrumental variable estimation (utilizing interaction of rs671 in ALDH2 and sex as an instrument) strengthens causal inference regarding the largely adverse influence of alcohol intake on cardiovascular health in an Asian population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.