Evidence map›Paper›PMID 26687854›Full record

ReviewSeminars in nuclear medicine2016

PET Neurochemical Imaging Modes.

Michael S Placzek, Wenjun Zhao, Hsiao-Ying Wey, Thomas M Morin, Jacob M Hooker

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in nuclear medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Detailed radiosynthesis of [Journal of labelled compounds & radiopharmaceuticals · 2023
    Article
  3. Review
  4. Article
  5. Review
  6. DirectJournal of the American Chemical Society · 2017
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Michael S PlaczekDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA; Department of Psychiatry, McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA.
Wenjun ZhaoDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.
Hsiao-Ying WeyDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA.
Thomas M MorinDepartment of Psychology, Tufts University, Medford, MA.
Jacob M HookerDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA. Electronic address: hooker@nmr.mgh.harvard.edu.
Athinoula A. Martinos Center for Biomedical Imaging · USHarvard University · USImaging Center · USMassachusetts General Hospital · USTufts University · US

Funding

Design of Class-specific HDAC Imaging Probes for Positron Emission TomographyR01DA030321 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI HOOKER, JACOB M. · 2010 to 2014
$2.4M
NIDA NIH HHS R01 DA030321
6 · The paper itself

Abstract

PET has deep roots in neuroscience stemming from its first application in brain tumor and brain metabolism imaging. PET emerged over the past few decades and continues to play a prominent role in the study of neurochemistry in the living human brain. Over time, neurochemical imaging with PET has been expanded to address a host of research questions related to, among many others, protein density, drug occupancy, and endogenous neurochemical release. Each of these imaging modes has distinct design and analysis considerations that are critical for enabling quantitative measurements. The number of considerations required for a neurochemical PET study can make it unapproachable. This article aims to orient those interested in neurochemical PET imaging to three of the common imaging modes and to provide some perspective on needs that exist for expansion of neurochemical PET imaging.

Indexed as

AnimalsHumansNeurochemistryNeurotransmitter AgentsPositron-Emission TomographyProteinsRadioactive TracersNeurotransmitter AgentsProteinsRadioactive Tracers

Identifiers

PMID26687854
PMCPMC5709996
OpenAlexW2190226906

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.