Evidence map›Paper›PMID 26687841›Full record

ArticleNeuron2016

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects.

Yang Zhou, Tobias Kaiser, Patrícia Monteiro, Xiangyu Zhang, Marie S Van der Goes, Dongqing Wang, Boaz Barak, Menglong Zeng, Chenchen Li, Congyi Lu and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 3 pooled it
21.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 3 syntheses or guidelines pooled it, 327 citations in OpenAlex.

  1. Pooled it
  2. MYT1L: A systematic review of genetic variation encompassing schizophrenia and autism.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020
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148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Yang ZhouMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China.
Tobias KaiserMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Patrícia MonteiroMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; PhD Program in Experimental Biology and Biomedicine (PDBEB), Center for Neuroscience and Cell Biology, University of Coimbra, 3000-214 Coimbra, Portugal.
Xiangyu ZhangMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Marie S Van der GoesMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Dongqing WangMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Boaz BarakMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Menglong ZengMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Division of Life Science, Center of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong.
Chenchen LiMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Congyi LuMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Michael WellsMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Aldo AmayaStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Shannon NguyenStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Michael LewisStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Neville SanjanaMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Yongdi ZhouKey Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China.
Mingjie ZhangDivision of Life Science, Center of Systems Biology and Human Health, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong.
Feng ZhangMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Zhanyan FuMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Guoping FengMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: fengg@mit.edu.
Massachusetts Institute of Technology · USMcGovern Institute for Brain Research · USBroad Institute · USHong Kong University of Science and Technology · HKEast China Normal University · CN

Funding

Massively-parallel functional interrogation of psychiatric geneticsR01MH110049 · NIMH · BROAD INSTITUTE, INC. · PI ZHANG, FENG · 2015 to 2019
$5.5M
Probing Neuropsychiatric Diseases Using Targeted Epigenome and Genome EngineeringDP1MH100706 · NIMH · BROAD INSTITUTE, INC. · PI ZHANG, FENG · 2012 to 2016
$4.3M
Shank3 in Synaptic Function and AutismR01MH097104 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FENG, GUOPING · 2012 to 2016
$2.0M
NCCDPHP CDC HHS DP1-MH100706NIMH NIH HHS 5R01MH097104NIMH NIH HHS DP1 MH100706NIMH NIH HHS R01 MH097104NIMH NIH HHS R01 MH110049NINDS NIH HHS R01-NS 07312401
6 · The paper itself

Abstract

Genetic studies have revealed significant overlaps of risk genes among psychiatric disorders. However, it is not clear how different mutations of the same gene contribute to different disorders. We characterized two lines of mutant mice with Shank3 mutations linked to ASD and schizophrenia. We found both shared and distinct synaptic and behavioral phenotypes. Mice with the ASD-linked InsG3680 mutation manifest striatal synaptic transmission defects before weaning age and impaired juvenile social interaction, coinciding with the early onset of ASD symptoms. On the other hand, adult mice carrying the schizophrenia-linked R1117X mutation show profound synaptic defects in prefrontal cortex and social dominance behavior. Furthermore, we found differential Shank3 mRNA stability and SHANK1/2 upregulation in these two lines. These data demonstrate that different alleles of the same gene may have distinct phenotypes at molecular, synaptic, and circuit levels in mice, which may inform exploration of these relationships in human patients.

Indexed as

Social BehaviorAgingAnimalsAutism Spectrum DisorderBehavior, AnimalDisease Models, AnimalHippocampusMice, TransgenicMicrofilament ProteinsMutationNerve Tissue ProteinsNeuronsSchizophreniaSynaptic TransmissionMicrofilament ProteinsNerve Tissue ProteinsSHANK1 protein, mouseShank2 protein, mouseShank3 protein, mouse

Identifiers

PMID26687841
PMCPMC4754122
OpenAlexW2196375380

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.