Evidence map›Paper›PMID 26687839›Full record

ArticleNeuron2016

Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes.

Ji-Ann Lee, Andrey Damianov, Chia-Ho Lin, Mariana Fontes, Neelroop N Parikshak, Erik S Anderson, Daniel H Geschwind, Douglas L Black, Kelsey C Martin

Open access · bronzeAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 1 pooled it
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 1 synthesis or guideline pooled it, 249 citations in OpenAlex.

  1. Pooled it
  2. Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2023
    Trial
  3. Article
  4. Article
  5. Article
  6. Corticosterone accelerates behavioral inflexibility via plasticity-related gene expression in the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Cell-Type-Specific Splicing of Transcription Regulators andThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  17. Article
  18. Article
  19. Cell-type-specific splicing of transcription regulators andbioRxiv : the preprint server for biology · 2024
    Article
  20. Review

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ji-Ann LeeDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Andrey DamianovDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Chia-Ho LinDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Mariana FontesDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Neelroop N ParikshakProgram in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Erik S AndersonDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Daniel H GeschwindProgram in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Douglas L BlackDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kelsey C MartinDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: kcmartin@mednet.ucla.edu.
University of California, Los Angeles · USHoward Hughes Medical Institute · US

Funding

Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 2007 to 2021
$32.0M
Localized mRNAs in Synaptic PlasticityR01NS045324 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, KELSEY C · 2003 to 2013
$2.8M
Genomic Measurement of Alternative SplicingR01GM084317 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ARES, MANUEL, YEO, EUGENE WEI-MING · 2009 to 2012
$1.8M
Cytoplasmic Functions of Rbfox1, a Candidate Autism GeneR21MH101684 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, KELSEY C · 2013 to 2014
$424k
Characterization of Small Molecule Splicing Modulators of MAPT and FGFR1F30AG033993 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANDERSON, ERIK S · 2009 to 2011
$92k
Transcriptional Regulators in Normal Human Brain Development and AutismF30MH099886 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PARIKSHAK, NEELROOP NARENDRA · 2012 to 2015
$85k
Howard Hughes Medical InstituteNIA NIH HHS 4F30AG033993NIA NIH HHS F30 AG033993NICHD NIH HHS P50 HD055784NICHD NIH HHS P50-HD-055784NIGMS NIH HHS R01 GM084317NIMH NIH HHS F30 MH099886NIMH NIH HHS F30MH099886NIMH NIH HHS R21 MH101684NINDS NIH HHS R01 NS045324
6 · The paper itself

Abstract

Human genetic studies have identified the neuronal RNA binding protein, Rbfox1, as a candidate gene for autism spectrum disorders. While Rbfox1 functions as a splicing regulator in the nucleus, it is also alternatively spliced to produce cytoplasmic isoforms. To investigate the function of cytoplasmic Rbfox1, we knocked down Rbfox proteins in mouse neurons and rescued with cytoplasmic or nuclear Rbfox1. Transcriptome profiling showed that nuclear Rbfox1 rescued splicing changes, whereas cytoplasmic Rbfox1 rescued changes in mRNA levels. iCLIP-seq of subcellular fractions revealed that Rbfox1 bound predominantly to introns in nascent RNA, while cytoplasmic Rbox1 bound to 3' UTRs. Cytoplasmic Rbfox1 binding increased target mRNA stability and translation, and Rbfox1 and miRNA binding sites overlapped significantly. Cytoplasmic Rbfox1 target mRNAs were enriched in genes involved in cortical development and autism. Our results uncover a new Rbfox1 regulatory network and highlight the importance of cytoplasmic RNA metabolism to cortical development and disease.

Indexed as

Alternative SplicingAnimalsAutistic DisorderBrainCytoplasmEstriolGene Expression ProfilingHumansMice, Inbred C57BLNeuronsRNA-Binding ProteinsRNA, MessengerRNA Splicing FactorsEstriolestriol succinateRBFOX1 protein, humanRbfox1 protein, mouseRNA-Binding ProteinsRNA, MessengerRNA Splicing Factors

Identifiers

PMID26687839
PMCPMC4858412
OpenAlexW2190411440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.