Evidence map›Paper›PMID 26687819›Full record

ArticleCancer2016

Working after a metastatic cancer diagnosis: Factors affecting employment in the metastatic setting from ECOG-ACRIN's Symptom Outcomes and Practice Patterns study.

Amye J Tevaarwerk, Ju-Whei Lee, Abigail Terhaar, Mary E Sesto, Mary Lou Smith, Charles S Cleeland, Michael J Fisch

Abstract readMulticenter Study
In one paragraph

Article in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Prognostic factors for return to work in breast cancer survivors.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Factors associated with employment outcomes in cancer survivors: a systematic scoping review spanning a decade of international research.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Financial toxicity among people with metastatic cancer: findings from the Cancer Experience Registry.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Unmet needs and problems related to employment and working as reported by survivors with metastatic breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amye J TevaarwerkUniversity of Wisconsin-Madison, Madison, Wisconsin.
Ju-Whei LeeDana-Farber Cancer Institute, Boston, Massachusetts.
Abigail TerhaarUniversity of Wisconsin-Madison, Madison, Wisconsin.
Mary E SestoUniversity of Wisconsin-Madison, Madison, Wisconsin.
Mary Lou SmithResearch Advocacy Network.
Charles S CleelandThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Michael J FischThe University of Texas MD Anderson Cancer Center, Houston, Texas.

Funding

ECOG-ACRIN NCORP Research Base - TMISTUG1CA189828 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer, MITCHELL D. SCHNALL · 2014 to 2026
$199.7M
ECOG OPERATIONS OFFICE (IBCSG)U10CA021115 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI COMIS, ROBERT L · 1985 to 2013
$132.6M
Foreign Accrual - ECOGU10CA037403 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI COMIS, ROBERT L · 1985 to 2014
$34.6M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
EASTERN COOPERATIVE ONCOLOGY GROUP CHAIR'S OFFICEU10CA086802 · NCI · MCP HAHNEMANN UNIVERSITY · PI COMIS, ROBERT L · 1999 to 2013
$13.3M
Institutional Clinical and Translational Science Award (UW-Madison)KL2RR025012 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$11.1M
EASTERN COOPERATIVE ONCOLOGY GROUP--WISCONSIN STUDIESU10CA021076 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KAHL, BRAD · 1985 to 2013
$8.2M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
ECOG Clinical TrialsU10CA017145 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BENSON, AL B · 1985 to 2013
$6.1M
UT MD Anderson Cancer Center Network Lead Academic Participating Site (LAP)U10CA180858 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HUNT, KELLY K, PINNIX, CHELSEA CAMILLE · 2014 to 2018
$5.6M
ONCOLOGYU10CA015488 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LUGER, SELINA M · 1985 to 2013
$5.6M
NCATS NIH HHS KL2 TR000428NCATS NIH HHS UL1 TR000427NCI NIH HHS CA180799NCI NIH HHS CA180858NCI NIH HHS U10 CA015488NCI NIH HHS U10 CA017145NCI NIH HHS U10 CA021076NCI NIH HHS U10 CA021115NCI NIH HHS U10 CA037403NCI NIH HHS U10 CA086802NCI NIH HHS UG1 CA189828NCRR NIH HHS KL2 RR025012NCRR NIH HHS UL1 RR025011
6 · The paper itself

Abstract

backgroundImproved survival for individuals with metastatic cancer accentuates the importance of employment for cancer survivors. A better understanding of how metastatic cancer affects employment is a necessary step toward the development of tools for assisting survivors in this important realm.

methodsThe ECOG-ACRIN Symptom Outcomes and Practice Patterns study was analyzed to investigate what factors were associated with the employment of 680 metastatic cancer patients. Univariate and multivariate logistic regression analyses were conducted to compare patients stably working with patients no longer working.

resultsThere were 668 metastatic working-age participants in the analysis: 236 (35%) worked full- or part-time, whereas 302 (45%) had stopped working because of illness. Overall, 58% reported some change in employment due to illness. A better performance status and non-Hispanic white ethnicity/race were significantly associated with continuing to work despite a metastatic cancer diagnosis in the multivariate analysis. The disease type, time since metastatic diagnosis, number of metastatic sites, location of metastatic disease, and treatment status had no significant impact. Among the potentially modifiable factors, receiving hormonal treatment (if a viable option) and decreasing symptom interference were associated with continuing to work.

conclusionsA significant percentage of the metastatic patients remained employed; increased symptom burden was associated with a change to no longer working. Modifiable factors resulting in work interference should be minimized so that patients with metastatic disease may continue working if this is desired. Improvements in symptom control and strategies developed to help address workplace difficulties have promise for improving this aspect of survivorship.

Indexed as

Neoplasm MetastasisAdultBreast NeoplasmsColorectal NeoplasmsDisease ProgressionEmploymentFemaleHumansLogistic ModelsLung NeoplasmsMaleMiddle AgedNeoplasmsPeruPrevalenceProspective Studiesadvanced canceremploymentmetastatic cancersymptom burdentreatment toxicity

Identifiers

PMID26687819
PMCPMC4724218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.