Evidence map›Paper›PMID 26687367›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2016

Stereotactic body radiation therapy and intensity modulated radiation therapy induce different plasmatic cytokine changes in non-small cell lung cancer patients: a pilot study.

M Trovo, N Giaj-Levra, C Furlan, M T Bortolin, E Muraro, J Polesel, E Minatel, R Tedeschi, A R Filippi, F Alongi and 1 more

Abstract read
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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Cytokines and radiation-induced pulmonary injuries.Journal of radiation research · 2018
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

M TrovoDepartment of Radiation Oncology, Centro di Riferimento Oncologico of Aviano, Aviano, Italy.
N Giaj-LevraRadiation Oncology, Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni 5, Negrar, 37024, Verona, Italy. gmnicco@yahoo.it.
C FurlanDepartment of Radiation Oncology, Centro di Riferimento Oncologico of Aviano, Aviano, Italy.
M T BortolinDepartment of Microbiology-Immunology and Virology, Centro di Riferimento Oncologico of Aviano, Aviano, Italy.
E MuraroDepartment of Translational Research, Centro di Riferimento Oncologico of Aviano, Aviano, Italy.
J PoleselDepartment of Epidemiology and Biostatistics, Centro di Riferimento Oncologico of Aviano, Aviano, Italy.
E MinatelDepartment of Radiation Oncology, Centro di Riferimento Oncologico of Aviano, Aviano, Italy.
R TedeschiDepartment of Microbiology-Immunology and Virology, Centro di Riferimento Oncologico of Aviano, Aviano, Italy.
A R FilippiDepartment of Oncology, University of Torino, Turin, Italy.
F AlongiRadiation Oncology, Sacro Cuore Don Calabria Hospital, Via Don A. Sempreboni 5, Negrar, 37024, Verona, Italy.
U RicardiDepartment of Oncology, University of Torino, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess kinetics of plasmatic cytokines during radiation therapy (RT) for locally advanced and early-stage non-small cell lung cancer (NSCLC).

methodsThis prospective study was conducted on 15 early-stage NSCLC underwent to extreme hypofractionated regimen (52 Gy in 8 fractions) with stereotactic body RT (SBRT), and 13 locally advanced NSCLC underwent to radical moderated hypofractionated regimen (60 Gy in 25 fractions) with intensity modulated RT (IMRT). For patients undergoing SBRT, peripheral blood samples were collected on the first day of SBRT (TFd), the last day (TLd) and 45 days (T45d) after the end of SBRT. For patients undergoing IMRT, blood samples were collected at: TFd, 2 weeks (T2w), 4 weeks (T4w), TLd, and T45d. The following cytokines were measured: IL-1, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-15, IL-17A, EGF, FGF-2, INF-γ, MIP-1α, MIP-1β, TGF-α, TNF-α, and VEGF. Cytokine levels measured in different RT time and compared.

resultsNo difference in baseline levels of cytokines was documented between patient radiation approaches (except for MIP-1α). For SBRT patients, a mean reduction of IL-10 and IL-17 plasma level was documented between TLd and TFd, respectively (p < 0.05). For IMRT patients, a statistically significant (p < 0.05) mean plasma level reduction was documented between T4w and TFd for all the following cytokines: IL-1, IL-1ra, IL-2, IL-12, FGF-2, MIP-1α, MIP-1β, TGF-α, TNF-α, VEGF.

conclusionsSBRT and IMRT induce different plasmatic cytokine changes in NSCLC patients, supporting hypothesis that RT regimes of dose schedules and techniques have different impacts on the host immune response.

Indexed as

AdenocarcinomaAgedAged, 80 and overBiomarkers, TumorCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCytokinesFemaleFollow-Up StudiesHumansImmunoenzyme TechniquesLung NeoplasmsMaleMiddle AgedNeoplasm StagingPilot ProjectsBiomarkers, TumorCytokinesCytokinesIntensity modulated radiotherapyNon-small cell lung cancerStereotactic ablative radiotherapy

Identifiers

PMID26687367

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.