ArticleScientific reports2015
Constructive remodeling of a synthetic endothelial extracellular matrix.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- An integrated design strategy for structurally stable full-thickness human skin models with regulatory-qualified barrier assessment.Materials today. Bio · 2026Article
- Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases.American heart journal plus : cardiology research and practice · 2025Review
- Microfluidic model for in vitro acute Toxoplasma gondii infection and transendothelial migration.Scientific reports · 2022Article
- Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity.Bioactive materials · 2021Review
- Article
- Tissue-engineered vascular microphysiological platform to study immune modulation of xenograft rejection.Science advances · 2021Article
- Remodeling of the Microvasculature: May the Blood Flow Be With You.Frontiers in physiology · 2020Review
- Obesity-Associated Extracellular Matrix Remodeling Promotes a Macrophage Phenotype Similar to Tumor-Associated Macrophages.The American journal of pathology · 2019Article
- Macrophages-Triggered Sequential Remodeling of Endothelium-Interstitial Matrix to Form Pre-Metastatic Niche in Microfluidic Tumor Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- A high-throughput microtissue platform to probe endothelial function in vitro.Integrative biology : quantitative biosciences from nano to macro · 2018Article
- Review Article: Capturing the physiological complexity of the brain's neuro-vascular unitBiomicrofluidics · 2018Review
- Future Research Directions in the Design of Versatile Extracellular Matrix in Tissue Engineering.International neurourology journal · 2018Article
- Hydrophobic Patterning-Based 3D Microfluidic Cell Culture Assay.Advanced healthcare materials · 2018Article
- Elastic Fibers and Large Artery Mechanics in Animal Models of Development and Disease.Journal of biomechanical engineering · 2018Review
- Current Challenges in Translating Tissue-Engineered Heart Valves.Current treatment options in cardiovascular medicine · 2017Review
- Vasculature-On-A-Chip for In Vitro Disease Models.Bioengineering (Basel, Switzerland) · 2017Review
- Screening out irrelevant cell-based models of disease.Nature reviews. Drug discovery · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The construction of well-controllable in vitro models of physiological and pathological vascular endothelium remains a fundamental challenge in tissue engineering and drug development. Here, we present an approach for forming a synthetic endothelial extracellular matrix (ECM) that closely resembles that of the native structure by locally depositing basement membrane materials onto type 1 collagen nanofibers only in a region adjacent to the endothelial cell (EC) monolayer. Culturing the EC monolayer on this synthetic endothelial ECM remarkably enhanced its physiological properties, reducing its vascular permeability, and promoting a stabilized, quiescent phenotype. We demonstrated that the EC monolayer on the synthetic endothelial ECM neither creates non-physiological barriers to cell-cell or cell-ECM interactions, nor hinders molecular diffusion of growth factors and other molecules. The synthetic endothelial ECM and vascular endothelium on it may help us enter in a new phase of research in which various models of the biological barrier behavior can be tested experimentally.
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