ArticleScientific reports2015
Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium?
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis.Frontiers in immunology · 2024Pooled it
- Pooled it
- Models to predict the public health impact of vaccine resistance: A systematic review.Vaccine · 2019Pooled it
- Impact of dosing schedules on performance of rotavirus vaccines in Ghana.Science advances · 2024Article
- Generation of Recombinant Authentic Live Attenuated Human Rotavirus Vaccine Strain RIX4414 (RotarixViruses · 2024Article
- Impact of dosing schedules on performance of rotavirus vaccines in Ghana.medRxiv : the preprint server for health sciences · 2024Article
- Prediction of effectiveness of universal rotavirus vaccination in Southwestern Vietnam based on a dynamic mathematical model.Scientific reports · 2024Article
- Rotavirus genotypes and clinical outcome of natural infection based on vaccination status in the post-vaccine era.Human vaccines & immunotherapeutics · 2022Article
- Rotavirus Genotypes in Hospitalized Children With Acute Gastroenteritis Before and After Rotavirus Vaccine Introduction in Blantyre, Malawi, 1997-2019.The Journal of infectious diseases · 2022Article
- The Long-Term Impact of Rotavirus Vaccines in Korea, 2008-2020; Emergence of G8P[8] Strain.Vaccines · 2021Article
- Rotavirus vaccine effectiveness and impact in Uzbekistan, the first country to introduce in central Asia.Human vaccines & immunotherapeutics · 2021Article
- Multiple Introductions and Predominance of Rotavirus Group A Genotype G3P[8] in Kilifi, Coastal Kenya, 4 Years after Nationwide Vaccine Introduction.Pathogens (Basel, Switzerland) · 2020Article
- Epidemiological Trends of Five Common Diarrhea-Associated Enteric Viruses Pre- and Post-Rotavirus Vaccine Introduction in Coastal Kenya.Pathogens (Basel, Switzerland) · 2020Article
- Overview of the Development, Impacts, and Challenges of Live-Attenuated Oral Rotavirus Vaccines.Vaccines · 2020Review
- Group A Rotavirus Detection and Genotype Distribution before and after Introduction of a National Immunisation Programme in Ireland: 2015-2019.Pathogens (Basel, Switzerland) · 2020Article
- Evaluating strategies to improve rotavirus vaccine impact during the second year of life in Malawi.Science translational medicine · 2019Article
- Experiences with rotavirus vaccines: can we improve rotavirus vaccine impact in developing countries?Human vaccines & immunotherapeutics · 2019Review
- Temporal association of rotavirus vaccination and genotype circulation in South Africa: Observations from 2002 to 2014.Vaccine · 2018Article
- A Multiplex PCR/LDR Assay for Viral Agents of Diarrhea with the Capacity to Genotype Rotavirus.Scientific reports · 2018Article
- Molecular-Genetic Characterization of Human Rotavirus A Strains Circulating in Moscow, Russia (2009-2014).Virologica Sinica · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Vaccination can place selective pressures on viral populations, leading to changes in the distribution of strains as viruses evolve to escape immunity from the vaccine. Vaccine-driven strain replacement is a major concern after nationwide rotavirus vaccine introductions. However, the distribution of the predominant rotavirus genotypes varies from year to year in the absence of vaccination, making it difficult to determine what changes can be attributed to the vaccines. To gain insight in the underlying dynamics driving changes in the rotavirus population, we fitted a hierarchy of mathematical models to national and local genotype-specific hospitalization data from Belgium, where large-scale vaccination was introduced in 2006. We estimated that natural- and vaccine-derived immunity was strongest against completely homotypic strains and weakest against fully heterotypic strains, with an intermediate immunity amongst partially heterotypic strains. The predominance of G2P[4] infections in Belgium after vaccine introduction can be explained by a combination of natural genotype fluctuations and weaker natural and vaccine-induced immunity against infection with strains heterotypic to the vaccine, in the absence of significant variation in strain-specific vaccine effectiveness against disease. However, the incidence of rotavirus gastroenteritis is predicted to remain low despite vaccine-driven changes in the distribution of genotypes.
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Registered trials
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