Evidence map›Paper›PMID 26687220›Full record

ArticleNeuron2015

In Vivo Imaging of Human Sarcomere Twitch Dynamics in Individual Motor Units.

Gabriel N Sanchez, Supriyo Sinha, Holly Liske, Xuefeng Chen, Viet Nguyen, Scott L Delp, Mark J Schnitzer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 73 citations in OpenAlex.

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  17. Variability ofFrontiers in physiology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gabriel N SanchezDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.
Supriyo SinhaDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
Holly LiskeDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.
Xuefeng ChenDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.
Viet NguyenDepartment of Neurology, Stanford University, Stanford, CA 94305, USA.
Scott L DelpDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA. Electronic address: delp@stanford.edu.
Mark J SchnitzerDepartment of Biology, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: mschnitz@stanford.edu.
Stanford University · US

Funding

National Center for Simulation in Rehabilitation ResearchR24HD065690 · NICHD · STANFORD UNIVERSITY · PI DELP, SCOTT L · 2010 to 2014
$4.2M
Howard Hughes Medical InstituteNICHD NIH HHS R24 HD065690
6 · The paper itself

Abstract

Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle's contractile units. Despite the motor unit's centrality to neuromuscular physiology, no extant technology can image sarcomere twitch dynamics in live humans. We created a wearable microscope equipped with a microendoscope for minimally invasive observation of sarcomere lengths and contractile dynamics in any major skeletal muscle. By electrically stimulating twitches via the microendoscope and visualizing the sarcomere displacements, we monitored single motor unit contractions in soleus and vastus lateralis muscles of healthy individuals. Control experiments verified that these evoked twitches involved neuromuscular transmission and faithfully reported muscle force generation. In post-stroke patients with spasticity of the biceps brachii, we found involuntary microscopic contractions and sarcomere length abnormalities. The wearable microscope facilitates exploration of many basic and disease-related neuromuscular phenomena never visualized before in live humans.

Indexed as

AdultAnimalsElectric StimulationEndoscopyFemaleHumansMaleMiceMice, Inbred C57BLMicroscopy, PolarizationMiddle AgedMuscle ContractionRecruitment, NeurophysiologicalSarcomeresYoung Adult

Identifiers

PMID26687220
PMCPMC5920519
OpenAlexW2213635980

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.