ArticlePhotochemistry and photobiology2016
Proteomonas sulcata ACR1: A Fast Anion Channelrhodopsin.
Article in Photochemistry and photobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Tutorial: Transient Absorption Spectroscopy for Probing Ultrafast Dynamics.ACS physical chemistry Au · 2026Article
- Optogenetic Control of Heart Rhythm: Lightly Guiding the Cardiac Pace.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Preference of Proteomonas sulcata anion channelrhodopsin for NOScientific reports · 2021Article
- Emerging Diversity of Channelrhodopsins and Their Structure-Function Relationships.Frontiers in cellular neuroscience · 2021Review
- Fiberless Optogenetics.Advances in experimental medicine and biology · 2021Article
- Molecular Dynamics Simulation of Transmembrane Transport of Chloride Ions in Mutants of Channelrhodopsin.Biomolecules · 2019Article
- MerMAIDs: a family of metagenomically discovered marine anion-conducting and intensely desensitizing channelrhodopsins.Nature communications · 2019Article
- Multidimensional screening yields channelrhodopsin variants having improved photocurrent and order-of-magnitude reductions in calcium and proton currents.The Journal of biological chemistry · 2019Article
- Article
- Opsin 1 and Opsin 2 of the Corn Smut FungusFrontiers in microbiology · 2019Article
- Potassium channel-based optogenetic silencing.Nature communications · 2018Article
- Implications for the impairment of the rapid channel closing of Proteomonas sulcata anion channelrhodopsin 1 at high ClScientific reports · 2018Article
- Article
- Precise multimodal optical control of neural ensemble activity.Nature neuroscience · 2018Article
- Cardiac Electrophysiological Effects of Light-Activated Chloride Channels.Frontiers in physiology · 2018Article
- Bacteriorhodopsin-like channelrhodopsins: Alternative mechanism for control of cation conductance.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Review
- Microbial Rhodopsins: Diversity, Mechanisms, and Optogenetic Applications.Annual review of biochemistry · 2017Review
- Whole-cell Patch-clamp Recordings for Electrophysiological Determination of Ion Selectivity in Channelrhodopsins.Journal of visualized experiments : JoVE · 2017Article
- Structural Changes in an Anion Channelrhodopsin: Formation of the K and L Intermediates at 80 K.Biochemistry · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Natural channelrhodopsins with strictly anion selectivity and high unitary conductance have been recently discovered in the cryptophyte alga Guillardia theta. These proteins, called anion channelrhodopsins (ACRs), are of interest for their novel function and also because they were shown to be highly efficient tools to inhibit neuronal action potentials with light. We show that a homologous protein from the cryptophyte alga Proteomonas sulcata (named here PsuACR1) exhibits similar strict anion selectivity as the previously identified G. theta ACRs. Like G. theta ACRs, PsuACR1 lacks a protonatable residue at the position of the proton acceptor Asp-85 in bacteriorhodopsin, which may be a key characteristic of ACR family members shared by haloarchaeal chloride pumps. Of importance for its potential use in optogenetics, despite its 10-fold lower channel activity than the GtACRs, PsuACR1 exhibits an ~eightfold more rapid channel closing half-time making it uniquely suitable for silencing the subclass of high-frequency firing neurons when high-time resolution is needed. The existence of a rhodopsin with properties similar to G. theta ACRs in a different cryptophyte genus indicates that such proteins may be widespread in the phylum of cryptophyte algae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.