ArticleJournal of atherosclerosis and thrombosis2016
HDL2/HDL3 Ratio Changes, Metabolic Syndrome Markers, and Other Factors in a Japanese Population.
Article in Journal of atherosclerosis and thrombosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Association Between HDL2-C and HDL3-C with Cardiovascular Disease: A Nested Case-Control Study in an Iranian Population.International journal of endocrinology and metabolism · 2024Article
- Protective and therapeutic potentials of HDL and ApoA1 in COVID-19 elderly and chronic illness patients.Bulletin of the National Research Centre · 2022Review
- Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk: Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity.Frontiers in physiology · 2018Article
- Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study.Journal of atherosclerosis and thrombosis · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIM AND
methodsThe high-density lipoprotein 2 cholesterol (HDL2-C) to HDL3-C ratio is associated with insulin resistance, high-molecular-weight adiponectin (HMW-Ad), and metabolic syndrome (MetS) components and is useful for evaluating MetS in Japanese individuals. We investigated potential associations between changes in HDL2-C/HDL3-C and changes in MetS components, insulin resistance, adipocytokine, lipids, and lifestyle habits in 892 Japanese subjects who underwent annual health examinations twice at a mean interval of 1.1 years. Study subjects were divided into three groups on the basis of HDL2-C/HDL3-C changes.
resultsAverage changes in waist circumference (WC) and HDL-C were significantly lower and higher, respectively, in the 0 to ＜0.5 and ≥0.5 HDL2-C/HDL3-C change groups compared with those in the reference group (＜0 HDL2-C/HDL3-C change). Among MetS components, average changes in HDL2-C/HDL3-C were associated with changes in WC and HDL-C. Average changes in HMW-Ad and the homeostasis model assessment of insulin resistance were significantly higher and lower, respectively, in the ≥0.5 HDL2-C/HDL3-C change group compared with those in the reference group. In addition, the average low-density lipoprotein cholesterol (LDL-C) gradually decreased as HDL2-C/HDL3-C increased. The average change in LDL-C was significantly lower in the 0 to ＜0.5 and ≥0.5 HDL2-C/HDL3-C change groups than in the reference group. Moreover, a ≥0.5 HDL2-C/HDL3-C change positively correlated with good lifestyle statuses in terms of smoking, physical activity, and alcohol consumption.
conclusionChanges in HDL2-C/HDL3-C inversely correlated with changes in WC, insulin resistance, and LDL-C and positively correlated with HMW-Ad and good lifestyle habits. Therefore, HDL2-C/HDL3-C changes comprise a useful marker for both MetS and atherogenic conditions in Japanese population.
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