ArticleHuman brain mapping2016
Reorganization of functionally connected brain subnetworks in high-functioning autism.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- Naturalistic stimuli in neuroimaging studies of autism spectrum disorder: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Early development of cortical networks is modulated by Family Nurture Intervention: a multicenter replication study.Pediatric research · 2026Article
- The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders.Nature neuroscience · 2026Article
- Aberrant type 2 dopamine and mu-opioid receptor availability in autism spectrum disorder.European journal of nuclear medicine and molecular imaging · 2026Article
- Shared orbitofrontal dynamics to a drug-themed movie track craving and recovery in heroin addiction.Brain : a journal of neurology · 2025Article
- Function of the auditory cortex characterized by its intrinsic dynamic coactivation patterns estimated in individuals.bioRxiv : the preprint server for biology · 2025Article
- Individual connectivity-based parcellations reflect functional properties of human auditory cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Restless reachability problems in temporal graphs.Knowledge and information systems · 2025Article
- Real-world goal-directed behavior reveals aberrant functional brain connectivity in children with ADHD.PloS one · 2025Article
- A lightweight, end-to-end explainable, and generalized attention-based graph neural network model trained on high-order spatiotemporal organization of dynamic functional connectivity to classify autistics from typically developing.Network neuroscience (Cambridge, Mass.) · 2025Article
- Atypical Brain Connectivity During Pragmatic and Semantic Language Processing in Children with Autism.Brain sciences · 2024Article
- Relatively Inefficient Integration of Metaphorical Semantics in Autistic Adults Without Intellectual Impairment.Journal of autism and developmental disorders · 2024Article
- Naturalistic drug cue reactivity in heroin use disorder: orbitofrontal synchronization as a marker of craving and recovery.medRxiv : the preprint server for health sciences · 2024Article
- High performers demonstrate greater neural synchrony than low performers across behavioral domains.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Probing the overarching continuum theory: data-driven phenotypic clustering of children with ASD or ADHD.European child & adolescent psychiatry · 2023Article
- Individual differences in neural event segmentation of continuous experiences.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neural responses to biological motion distinguish autistic and schizotypal traits.Social cognitive and affective neuroscience · 2023Article
- Increased flexibility of brain dynamics in patients with multiple sclerosis.Brain communications · 2023Article
- Aberrant motor contagion of emotions in psychopathy and high-functioning autism.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Alterations in Social Brain Network Topology at Rest in Children With Autism Spectrum Disorder.Psychiatry investigation · 2022Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Previous functional connectivity studies have found both hypo- and hyper-connectivity in brains of individuals having autism spectrum disorder (ASD). Here we studied abnormalities in functional brain subnetworks in high-functioning individuals with ASD during free viewing of a movie containing social cues and interactions. Twenty-six subjects (13 with ASD) watched a 68-min movie during functional magnetic resonance imaging. For each subject, we computed Pearson's correlation between haemodynamic time-courses of each pair of 6-mm isotropic voxels. From the whole-brain functional networks, we derived individual and group-level subnetworks using graph theory. Scaled inclusivity was then calculated between all subject pairs to estimate intersubject similarity of connectivity structure of each subnetwork. Additional 54 individuals (27 with ASD) from the ABIDE resting-state database were included to test the reproducibility of the results. Between-group differences were observed in the composition of default-mode and ventro-temporal-limbic (VTL) subnetworks. The VTL subnetwork included amygdala, striatum, thalamus, parahippocampal, fusiform, and inferior temporal gyri. Further, VTL subnetwork similarity between subject pairs correlated significantly with similarity of symptom gravity measured with autism quotient. This correlation was observed also within the controls, and in the reproducibility dataset with ADI-R and ADOS scores. Our results highlight how the reorganization of functional subnetworks in individuals with ASD clarifies the mixture of hypo- and hyper-connectivity findings. Importantly, only the functional organization of the VTL subnetwork emerges as a marker of inter-individual similarities that co-vary with behavioral measures across all participants. These findings suggest a pivotal role of ventro-temporal and limbic systems in autism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.