ArticleCell reports2015
Controlling the Cyanobacterial Clock by Synthetically Rewiring Metabolism.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Circadian temperature compensation is intrinsically linked with metabolism and redox signaling.Nature communications · 2026Article
- Cyanobacterial Circadian Clock: Molecular Mechanisms and Physiological Outputs.Plants (Basel, Switzerland) · 2026Review
- The free-running property of circadian clocks is needed to tolerate changing photoperiods.Current biology : CB · 2026Article
- Autonomous Redox Rhythms and Their Coupling to the Circadian Clock.Advances in experimental medicine and biology · 2026Review
- Self-sustained rhythmic behavior ofPNAS nexus · 2025Article
- Two KaiABC systems control circadian oscillations in one cyanobacterium.Nature communications · 2024Article
- Emergence of metabolic coupling to the heterotrophISME communications · 2024Article
- Circadian coordination: understanding interplay between circadian clock and mitochondria.Animal cells and systems · 2024Review
- Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping.International journal of molecular sciences · 2023Review
- Microbial circadian clocks: host-microbe interplay in diel cycles.BMC microbiology · 2023Review
- Circadian entrainment of in vitro reactions, in real time, and around the clock.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Performance Prediction of Fundamental Transcriptional Programs.ACS synthetic biology · 2023Article
- Synchronization of the circadian clock to the environment tracked in real time.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Glycogen metabolism is required for optimal cyanobacterial growth in the rapid light-dark cycle of low-Earth orbit.Life sciences in space research · 2023Article
- Review
- Differential Timing for Glucose Assimilation inMicrobiology spectrum · 2022Article
- Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism.Nature reviews. Gastroenterology & hepatology · 2021Review
- The circadian clock ensures successful DNA replication in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Critical Role of Light in the Growth and Activity of the Marine NFrontiers in microbiology · 2021Article
- Engineered systems of inducible anti-repressors for the next generation of biological programming.Nature communications · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Circadian clocks are oscillatory systems that allow organisms to anticipate rhythmic changes in the environment. Several studies have shown that circadian clocks are connected to metabolism, but it is not generally clear whether metabolic signaling is one voice among many that influence the clock or whether metabolic cycling is the major clock synchronizer. To address this question in cyanobacteria, we used a synthetic biology approach to make normally autotrophic cells capable of growth on exogenous sugar. This allowed us to manipulate metabolism independently from light and dark. We found that feeding sugar to cultures blocked the clock-resetting effect of a dark pulse. Furthermore, in the absence of light, the clock efficiently synchronizes to metabolic cycles driven by rhythmic feeding. We conclude that metabolic activity, independent of its source, is the primary clock driver in cyanobacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.