ArticleSeminars in thoracic and cardiovascular surgery2015
Trends in U.S. Extracorporeal Membrane Oxygenation Use and Outcomes: 2002-2012.
Article in Seminars in thoracic and cardiovascular surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 80 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post-Cardiotomy Extra-Corporeal Life Support Study: a Retrospective International Multicenter Cohort Study
Innovative Solutions to Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
A Prospective Single Center Study to Evaluate Safety and Efficacy of the EUROSETS Extracorporeal Membrane Oxygenation ECMOLIFE SYSTEM in Clinical Extracorporeal Life Support Applications EUROSETS ECMO STUDY
Assessing Brain Injury Using Portable Magnetic Resonance Imaging in Patients With Extracorporeal Membrane Oxygenation
Who cites it
80 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Contemporary approaches to extracorporeal membrane oxygenation usage in extended peripartum period over a decade - a systematic review.BMC pregnancy and childbirth · 2026Pooled it
- Effects of levosimendan on the outcome of veno-arterial extracorporeal membrane oxygenation: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Pooled it
- Intracranial hemorrhage in patients treated for SARS-CoV-2 with extracorporeal membrane oxygenation: A systematic review and meta-analysis.Journal of critical care · 2023Pooled it
- Understanding the "extracorporeal membrane oxygenation gap" in veno-arterial configuration for adult patients: Timing and causes of death.Artificial organs · 2021Pooled it
- Veno-Arterial Extracorporeal Life Support in Heart Transplant and Ventricle Assist Device Centres. Meta-analysis.ESC heart failure · 2021Pooled it
- The impact of Centre's heart transplant status and volume on in-hospital outcomes following extracorporeal membrane oxygenation for refractory post-cardiotomy cardiogenic shock: a meta-analysis.BMC cardiovascular disorders · 2020Pooled it
- Extracorporeal cardiopulmonary resuscitation for cardiac arrest: A systematic review.Resuscitation · 2018Pooled it
- ECMO and Short-term Support for Cardiogenic Shock in Heart Failure.Current cardiology reports · 2018Pooled it
- Death due to irreversible hypoxemic respiratory failure in ARDSnet clinical trials.Journal of critical care · 2022Trial
- Article
- Clinician Perspectives on the Extracorporeal Membrane Oxygenation Decision-Making Process.JAMA network open · 2026Article
- Outcomes and prediction of mortality in patients requiring prolonged veno-arterial extracorporeal membrane oxygenation support in the PRECISE-ECLS observational study.Critical care (London, England) · 2026Observational
- Article
- Extracorporeal Membrane Oxygenation (ECMO) and hospital economics.The journal of extra-corporeal technology · 2025Article
- Impact of pre-transplant veno-venous extracorporeal membrane oxygenation on post-lung transplant infections.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- National Outcomes of Venoarterial Extracorporeal Life Support in Patients with Chronic Kidney Disease.Surgery open science · 2025Article
- Prognostic Significance of Driving Pressure for Initiation and Maintenance of ECMO in Patients with Severe ARDS: A Systematic Review and Meta-analysis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Article
- Observational
- Ultra-Low-Field Portable MRI and Extracorporeal Membrane Oxygenation: Preclinical Safety Testing.Critical care explorations · 2024Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
This study evaluates contemporary trends in the use and outcomes of adult patients undergoing extracorporeal membrane oxygenation (ECMO) in U.S. hospitals. All adult discharges in the Nationwide Inpatient Sample database during the years 2002-2012 that included ECMO were used to estimate the total number of U.S. ECMO hospitalizations (n = 12,407). Diagnostic codes were used to group patients by indication for ECMO use into postcardiotomy, heart transplant, lung transplant, cardiogenic shock, respiratory failure, and cardiopulmonary failure. A Mann-Kendall test was used to examine trends over time using standard statistical techniques for survey data. We found that ECMO use increased significantly from 2002-2012 (P = 0.003), whereas in-hospital mortality rate fluctuated without a significant difference in trend over time. No significant trend was observed in overall ECMO use from 2002-2007, but the use did demonstrate a statistically significant increase from 2007-2012 (P = 0.0028). The highest in-hospital mortality rates were found in the postcardiotomy (57.2%) and respiratory failure (59.2%) groups. Lung and heart transplant groups had the lowest in-hospital mortality rates (44.10% and 45.31%, respectively). The proportion of ECMO use for postcardiotomy decreased from 56.9% in 2002 to 37.9% in 2012 (P = 0.026) and increased for cardiopulmonary failure from 3.9% to 11.1% (P = 0.026). We concluded that ECMO use in the United States increased between 2002 and 2012, driven primarily by increase in national ECMO use beginning in 2007. Mortality rates remained high but stable during this time period. Though there were shifts in relative ECMO use among patient groups, absolute ECMO use increased for all indications over the study period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.