Observational studyClinical rheumatology2016
Overweight older adults, particularly after an injury, are at high risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative.
Observational study in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Accelerated knee osteoarthritis: a case description and literature analysis.Quantitative imaging in medicine and surgery · 2025Article
- Global, regional, and national burden of knee osteoarthritis attributable to high BMI: a systematic analysis from 1990 to 2021 and projections to 2050.Frontiers in public health · 2025Article
- Clinical and imaging findings associated with preservation of knee joint health over 8 years in individuals aged 65 and over: data from the OAI.BMC musculoskeletal disorders · 2024Article
- Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis.Medicina (Kaunas, Lithuania) · 2024Article
- Physical Therapists' Attitudes, Beliefs, and Barriers Regarding Fall Screening and Prevention among Patients with Knee Osteoarthritis: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Efficacy ofFrontiers in pharmacology · 2023Article
- Risk factors and the natural history of accelerated knee osteoarthritis: a narrative review.BMC musculoskeletal disorders · 2020Review
- Common Musculoskeletal Disorders in the Elderly: The Star Triad.Journal of clinical medicine · 2020Review
- Occupational Activities: Factors That Tip the Balance From Bone Accrual to Bone Loss.Exercise and sport sciences reviews · 2020Review
- The incidence and characteristics of accelerated knee osteoarthritis among women: the Chingford cohort.BMC musculoskeletal disorders · 2020Article
- Longitudinal MRI structural findings observed in accelerated knee osteoarthritis: data from the Osteoarthritis Initiative.Skeletal radiology · 2019Observational
- Understanding Atherosclerosis Through an Osteoarthritis Data Set.Arteriosclerosis, thrombosis, and vascular biology · 2019Review
- Risk factors can classify individuals who develop accelerated knee osteoarthritis: Data from the osteoarthritis initiative.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Observational
- A single recent injury is a potent risk factor for the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative.Rheumatology international · 2017Article
- Glucose homeostasis influences the risk of incident knee osteoarthritis: Data from the osteoarthritis initiative.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Observational
- Knee symptoms among adults at risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative.Clinical rheumatology · 2017Observational
- Best performing definition of accelerated knee osteoarthritis: data from the Osteoarthritis Initiative.Therapeutic advances in musculoskeletal disease · 2016Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
We explored whether age and body mass index (BMI) can help identify a subset of individuals who are at high risk for accelerated knee osteoarthritis (AKOA) compared with common knee osteoarthritis (KOA). In the Osteoarthritis Initiative, a multicenter observational cohort study of KOA (n = 4796), we studied participants without KOA at baseline (Kellgren-Lawrence (KL) <2). Participants could have one of three outcomes: (1) AKOA, ≥1 knee progressed to end-stage KOA within 48 months; (2) common KOA, ≥1 knee increased in radiographic scoring within 48 months (excluding those with AKOA); and (3) no KOA, no change in KL grade in either knee. After verifying an interaction between age, BMI, and recent knee injury, we determined if we could identify a specific subset of individuals at high risk for AKOA instead of KOA. First, we reviewed three-dimensional graphs with age, BMI, and probability of AKOA versus KOA on the axes. We then conducted a logistic regression with AKOA as the outcome and age-BMI groups as the predictor. In our main analyses, we found that older individuals with a BMI <35 kg/m(2) were more likely to develop AKOA than common KOA (n = 64; mean [SD] BMI = 27.3 [3.1] kg/m(2); odds ratio = 3.47, 95 % confidence interval = 1.70 to 7.10), especially if they had a recent knee injury. While older age and greater BMI are independently associated with AKOA, we found that older individuals who had a higher BMI, particularly if they have an injury, were more likely to develop AKOA than common KOA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.