Evidence map›Paper›PMID 26686094›Full record

ArticleOncogene2016

Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis.

J-E Kim, E Roh, M H Lee, D H Yu, D J Kim, T-G Lim, S K Jung, C Peng, Y-Y Cho, S Dickinson and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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  15. Inhibitory Effect ofInternational journal of molecular sciences · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 3 countries.

J-E KimThe Hormel Institute, University of Minnesota, Austin, MN, USA.
E RohThe Hormel Institute, University of Minnesota, Austin, MN, USA.
M H LeeThe Hormel Institute, University of Minnesota, Austin, MN, USA.
D H YuThe Hormel Institute, University of Minnesota, Austin, MN, USA.
D J KimThe Hormel Institute, University of Minnesota, Austin, MN, USA.
T-G LimThe Hormel Institute, University of Minnesota, Austin, MN, USA.
S K JungThe Hormel Institute, University of Minnesota, Austin, MN, USA.
C PengThe Hormel Institute, University of Minnesota, Austin, MN, USA.
Y-Y ChoThe Hormel Institute, University of Minnesota, Austin, MN, USA.
S DickinsonUniversity of Arizona Cancer Center, Tucson, AZ, USA.
D AlbertsUniversity of Arizona Cancer Center, Tucson, AZ, USA.
G T BowdenUniversity of Arizona Cancer Center, Tucson, AZ, USA.
J EinspahrUniversity of Arizona Cancer Center, Tucson, AZ, USA.
S P StrattonUniversity of Arizona Cancer Center, Tucson, AZ, USA.
C Curiel-LewandrowskiUniversity of Arizona Cancer Center, Tucson, AZ, USA.
A M BodeThe Hormel Institute, University of Minnesota, Austin, MN, USA.
K W LeeDepartment of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Z DongThe Hormel Institute, University of Minnesota, Austin, MN, USA.
Hormel (United States) · USUniversity of Arizona · USAdvanced Institute of Convergence Technology · KRUniversity of Arizona Cancer CenterUniversity of Minnesota · USCatholic University of Korea · KRChina-US (Henan) Hormel Cancer Institute · CNSeoul National University · KR

Funding

VITAMIN A, AND ITS PRECURSORS AND DERIVATIVES AS THERAPEUTIC MODALITIESP01CA027502 · NCI · UNIVERSITY OF ARIZONA · PI EINSPAHR, JANINE G · 1985 to 2015
$36.3M
Ultraviolet-Induced Signal TrasductionR01CA077646 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DONG, ZIGANG · 1999 to 2010
$2.3M
Developing new ornithine decarboxylase inhibitors to prevent skin & colon cancerR01CA166011 · NCI · UNIVERSITY OF MINNESOTA · PI DONG, ZIGANG · 2013 to 2017
$1.6M
Anticarcinogenic Mechanisms of Tea ConstituentsR37CA081064 · NCI · UNIVERSITY OF MINNESOTA · PI DONG, ZIGANG · 2008 to 2012
$1.5M
Molecular Mechanisms and Targets of Soy Compounds in the Prevention of Colon CancR21CA172457 · NCI · UNIVERSITY OF MINNESOTA · PI DONG, ZIGANG · 2013 to 2014
$327k
NCI NIH HHS P01 CA027502NCI NIH HHS R01 CA077646NCI NIH HHS R01 CA166011NCI NIH HHS R21 CA172457NCI NIH HHS R37 CA081064
6 · The paper itself

Abstract

Solar ultraviolet (UV) light is a major etiological factor in skin carcinogenesis, with solar UV-stimulated signal transduction inducing pathological changes and skin damage. The primary sensor of solar UV-induced cellular signaling has not been identified. We use an experimental system of solar simulated light (SSL) to mimic solar UV and we demonstrate that Fyn is a primary redox sensor involved in SSL-induced signal transduction. Reactive oxygen species (ROS) generated by SSL exposure directly oxidize Cys488 of Fyn, resulting in increased Fyn kinase activity. Fyn oxidation was increased in mouse skin after SSL exposure and Fyn-knockout mice formed larger and more tumors compared with Fyn wild-type mice when exposed to SSL for an extended period of time. Murine embryonic fibroblasts (MEFs) lacking Fyn and cells in which Fyn expression was knocked down were resistant to SSL-induced apoptosis. Furthermore, cells expressing mutant Fyn (C448A) were resistant to SSL-induced apoptosis. These findings suggest that Fyn acts as a regulatory nexus between solar UV, ROS and signal transduction during skin carcinogenesis.

Indexed as

AnimalsApoptosisCells, CulturedMiceMice, HairlessNeoplasms, Radiation-InducedProtein Kinase C-deltaProto-Oncogene Proteins c-fynReactive Oxygen SpeciesSignal TransductionSkin NeoplasmsUltraviolet RaysFyn protein, mousePrkcd protein, mouseProtein Kinase C-deltaProto-Oncogene Proteins c-fynReactive Oxygen Species

Identifiers

PMID26686094
PMCPMC4916055
OpenAlexW2198764623

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.