ArticleScientific reports2015
Transcriptome analysis reveals mucin 4 to be highly associated with periodontitis and identifies pleckstrin as a link to systemic diseases.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Association between periodontitis and peripheral artery disease: a systematic review and meta-analysis.BMC cardiovascular disorders · 2018Pooled it
- Bacterial proteases and Bcl-2 proteins in peri-implant tissues: An exploratory cross-sectional study.Clinical oral investigations · 2026Article
- Multi-omics analysis identifies oxidative stress-related biomarkers and therapeutic targets linking periodontitis and ulcerative colitis via the oral-gut axis.Frontiers in immunology · 2026Article
- Immunologic cell deaths: involvement in the pathogenesis and intervention therapy of periodontitis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine.Human genomics · 2024Review
- In Vivo Regulation of Active Matrix Metalloproteinase-8 (aMMP-8) in Periodontitis: From Transcriptomics to Real-Time Online Diagnostics and Treatment Monitoring.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Analysis of immunogenic cell death in periodontitis based on scRNA-seq and bulk RNA-seq data.Frontiers in immunology · 2024Article
- Integrated Bioinformatic Analysis of Differentially Expressed Genes Associated with Wound Healing.Cell journal · 2023Article
- Identification and Validation of Immune-Related Genes Diagnostic for Progression of Atherosclerosis and Diabetes.Journal of inflammation research · 2023Article
- Identification of key genes as potential diagnostic and therapeutic targets for comorbidity of myasthenia gravis and COVID-19.Frontiers in neurology · 2023Article
- Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications.BMC genomics · 2022Article
- Classifying Integrated Signature Molecules in Macrophages of Rheumatoid Arthritis, Osteoarthritis, and Periodontal Disease: An Omics-Based Study.Current issues in molecular biology · 2022Article
- Expression and significance of mucin-4 and matrix metalloproteinase-7 in peri-implant disease.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022Article
- Genetic susceptibility to acute graft versus host disease in pediatric patients undergoing HSCT.Bone marrow transplantation · 2021Article
- Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease.eLife · 2021Article
- PANoptosis: A New Insight Into Oral Infectious Diseases.Frontiers in immunology · 2021Review
- Single-Cell RNA Sequencing Identifies New Inflammation-Promoting Cell Subsets in Asian Patients With Chronic Periodontitis.Frontiers in immunology · 2021Article
- Co-pathogens in Periodontitis and Inflammatory Bowel Disease.Frontiers in medicine · 2021Review
- Pleckstrin Levels Are Increased in Patients with Chronic Periodontitis and RegulatedFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multifactorial chronic inflammatory disease periodontitis, which is characterized by destruction of tooth-supporting tissues, has also been implicated as a risk factor for various systemic diseases. Although periodontitis has been studied extensively, neither disease-specific biomarkers nor therapeutic targets have been identified, nor its link with systemic diseases. Here, we analyzed the global transcriptome of periodontitis and compared its gene expression profile with those of other inflammatory conditions, including cardiovascular disease (CVD), rheumatoid arthritis (RA), and ulcerative colitis (UC). Gingival biopsies from 62 patients with periodontitis and 62 healthy subjects were subjected to RNA sequencing. The up-regulated genes in periodontitis were related to inflammation, wounding and defense response, and apoptosis, whereas down-regulated genes were related to extracellular matrix organization and structural support. The most highly up-regulated gene was mucin 4 (MUC4), and its protein product was confirmed to be over-expressed in periodontitis. When comparing the expression profile of periodontitis with other inflammatory diseases, several gene ontology categories, including inflammatory response, cell death, cell motion, and homeostatic processes, were identified as common to all diseases. Only one gene, pleckstrin (PLEK), was significantly overexpressed in periodontitis, CVD, RA, and UC, implicating this gene as an important networking link between these chronic inflammatory diseases.
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