Evidence map›Paper›PMID 26685668›Full record

ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2016

The Association of Neighborhood Gene-Environment Susceptibility with Cortisol and Blood Pressure in African-American Adults.

Sandra M Coulon, Dawn K Wilson, M L Van Horn, Gregory A Hand, Stephen Kresovich

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In one paragraph

Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Examining the Relationship between Mindfulness, Perceived Stress, and Blood Pressure in African-American College Students.Journal of best practices in health professions diversity : research, education and policy · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sandra M CoulonDepartment of Psychology, University of South Carolina, Barnwell College, Columbia, SC, 29201, USA. coulon@mailbox.sc.edu.
Dawn K WilsonDepartment of Psychology, University of South Carolina, Barnwell College, Columbia, SC, 29201, USA.
M L Van HornEducational Psychology, University of New Mexico, Albuquerque, NM, 87131, USA.
Gregory A HandSchool of Public Health, West Virginia University, Morgantown, WV, 26506, USA.
Stephen KresovichGenetics and Biochemistry, Clemson University, Clemson, SC, 29634, USA.

Funding

Biomedical-Behavioral Interface: Prevention and Developmental Sciences TrainingT32GM081740 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PRINZ, RONALD J · 2008 to 2022
$4.5M
Improving safety and access for physical activity supplementR01DK067615 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WILSON, DAWN K · 2007 to 2010
$3.2M
Families Improving Together (FIT) For Weight LossR01HD072153 · NICHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WILSON, DAWN K · 2012 to 2016
$2.9M
Social, Genetic Determinants of Blood Pressure in Underserved African AmericansF31AG039930 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI COULON, SANDRA MARIE · 2011 to 2013
$85k
NIA NIH HHS F31 AG039930NICHD NIH HHS R01 HD072153NICHD NIH HHS R01HD072153NIDDK NIH HHS R01 DK067615NIGMS NIH HHS T32 GM081740
6 · The paper itself

Abstract

backgroundAfrican-American adults are disproportionately affected by stress-related chronic conditions like high blood pressure (BP), and both environmental stress and genetic risk may play a role in its development. PURPOSE: This study tested whether the dual risk of low neighborhood socioeconomic status (SES) and glucocorticoid genetic sensitivity interacted to predict waking cortisol and BP.

methodsCross-sectional waking cortisol and BP were collected from 208 African-American adults who were participating in a follow-up visit as part of the Positive Action for Today's Health trial. Three single-nucleotide polymorphisms were genotyped, salivary cortisol samples were collected, and neighborhood SES was calculated using 2010 Census data.

resultsThe sample was mostly female (65 %), with weight classified as overweight or obese (M BMI = 32.74, SD = 8.88) and a mean age of 55.64 (SD = 15.21). The gene-by-neighborhood SES interaction predicted cortisol (B = 0.235, p = .001, r (2) = .036), but not BP. For adults with high genetic sensitivity, waking cortisol was lower with lower SES but higher with higher SES (B = 0.87). Lower neighborhood SES was also related to higher systolic BP (B = -0.794, p = .028).

conclusionsFindings demonstrated an interaction whereby African-American adults with high genetic sensitivity had high levels of waking cortisol with higher neighborhood SES, and low levels with lower neighborhood SES. This moderation effect is consistent with a differential susceptibility gene-environment pattern, rather than a dual-risk pattern. These findings contribute to a growing body of evidence that demonstrates the importance of investigating complex gene-environment relations in order to better understand stress-related health disparities.

Indexed as

Gene-Environment InteractionResidence CharacteristicsBlack or African AmericanBlood PressureCross-Sectional StudiesCyclin D1FemaleGenetic Predisposition to DiseaseGenotypeHumansHydrocortisoneMaleMiddle AgedPolymorphism, Single NucleotideReceptors, GlucocorticoidSalivaCyclin D1HydrocortisoneReceptors, GlucocorticoidTacrolimus Binding Protein 5Tacrolimus Binding ProteinsAfrican AmericanBlood pressureCortisolGeneticNeighborhoodSocioeconomic status

Identifiers

PMID26685668
PMCPMC5108625

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.