ArticleEuropean heart journal2017
Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo.
Article in European heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Randomized Comparison of Strut Coverage between Ticagrelor and Clopidogrel in Acute Myocardial Infarction at 3-Month Optical Coherence Tomography.Yonsei medical journal · 2018Trial
- Cholesterol and Albumin as Key Modulators of ICG Photostability in Aqueous Solution.Molecules (Basel, Switzerland) · 2026Article
- Optical theranostics in ischemic heart disease: from molecular insights to clinical translation.Theranostics · 2025Review
- What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?Frontiers in cardiovascular medicine · 2025Review
- Emerging Hybrid Intracoronary Imaging Technologies and Their Applications in Clinical Practice and Research.JACC. Cardiovascular interventions · 2024Review
- Ultrathin-strut versus thin-strut stent healing and outcomes in preclinical and clinical subjects.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Invasive coronary imaging of inflammation to further characterize high-risk lesions: what options do we have?Frontiers in cardiovascular medicine · 2024Review
- Evaluation of a Rabbit Model of Vascular Stent Healing: Application of Optical Coherence Tomography.Journal of cardiovascular translational research · 2023Article
- Intravascular Imaging for Guiding In-Stent Restenosis and Stent Thrombosis Therapy.Journal of the American Heart Association · 2022Review
- Imaging High-Risk Atherothrombosis Using a Novel Fibrin-Binding Positron Emission Tomography Probe.Stroke · 2022Article
- Intravascular Fluorescence Molecular Imaging of Atherosclerosis.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Let's embrace optical imaging: a growing branch on the clinical molecular imaging tree.European journal of nuclear medicine and molecular imaging · 2021Article
- Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.Journal of the American Heart Association · 2021Article
- Near-Infrared Autofluorescence in Atherosclerosis Associates With Ceroid and Is Generated by Oxidized Lipid-Induced Oxidative Stress.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Article
- Intracoronary optical coherence tomography: state of the art and future directions.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Article
- Coronary Stent Healing in Cancer Patients-An Optical Coherence Tomography Perspective.Frontiers in cardiovascular medicine · 2021Article
- Paclitaxel Drug-Coated Balloon Angioplasty Suppresses Progression and Inflammation of Experimental Atherosclerosis in Rabbits.JACC. Basic to translational science · 2020Article
- Atorvastatin ReducesJournal of the American Society of Nephrology : JASN · 2020Article
- Small Dimension-Big Impact! Nanoparticle-Enhanced Non-Invasive and Intravascular Molecular Imaging of Atherosclerosis In Vivo.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
aimsFibrin deposition and absent endothelium characterize unhealed stents that are at heightened risk of stent thrombosis. Optical coherence tomography (OCT) is increasingly used for assessing stent tissue coverage as a measure of healed stents, but cannot precisely identify whether overlying tissue represents physiological neointima. Here we assessed and compared fibrin deposition and persistence on bare metal stent (BMS) and drug-eluting stent (DES) using near-infrared fluorescence (NIRF) molecular imaging in vivo, in combination with simultaneous OCT stent coverage. METHODS AND
resultsRabbits underwent implantation of one BMS and one DES without overlap in the infrarenal aorta (N = 20 3.5 × 12 mm). At Days 7 and/or 28, intravascular NIRF-OCT was performed following the injection of fibrin-targeted NIRF molecular imaging agent FTP11-CyAm7. Intravascular NIRF-OCT enabled high-resolution imaging of fibrin overlying stent struts in vivo, as validated by histopathology. Compared with BMS, DES showed greater fibrin deposition and fibrin persistence at Days 7 and 28 (P < 0.01 vs. BMS). Notably, for edge stent struts identified as covered by OCT on Day 7, 92.8 ± 9.5% of DES and 55.8 ± 23.6% of BMS struts were NIRF fibrin positive (P < 0.001). At Day 28, 18.6 ± 10.6% (DES) and 5.1 ± 8.7% (BMS) of OCT-covered struts remained fibrin positive (P < 0.001).
conclusionIntravascular NIRF fibrin molecular imaging improves the detection of unhealed stents, using clinically translatable technology that complements OCT. A sizeable percentage of struts deemed covered by OCT are actually covered by fibrin, particularly in DES, and therefore such stents might remain prothrombotic. These findings have implications for the specificity of standalone clinical OCT assessments of stent healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.