Observational studyThe Journal of pediatrics2016
Assessment of Quality of Life in Young Patients with Single Ventricle after the Fontan Operation.
Observational study in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00132782 (Relationship Between Functional Health Status and Ventricular Performance After Fontan), which is not on this map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship Between Functional Health Status and Ventricular Performance After Fontan (A Trial Conducted by the Pediatric Heart Network)
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Health-related quality of life in adults with tetralogy of Fallot repair: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Pooled it
- Health-Related Quality of Life in Children, Adolescents, and Adults With a Fontan Circulation: A Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- What Do We Know About Young Adult Cardiac Patients' Experience? A Systematic Review.Frontiers in psychology · 2020Pooled it
- Systolic performance of the single ventricle, exercise capacity, and endothelial function in pediatric Fontan patients.American heart journal · 2025Trial
- Exercise Capacity, Endothelial Function, Muscle Mass, and Strength in Pediatric Patients With Fontan Circulation.CJC pediatric and congenital heart disease · 2026Article
- Health-Related Quality of Life in Children with Hypoplastic Left Heart Syndrome: Changes over Time and Associations with Neurodevelopmental and Clinical Factors.The Journal of pediatrics · 2026Article
- Fontan Route Remodeling over Time: A Longitudinal Quantitative 3D Case Series.Journal of cardiovascular development and disease · 2026Article
- Article
- Palliative care for the cardiothoracic transplant recipient.JHLT open · 2025Article
- Quality of Life in the Danish Fontan Population is Unchanged Over the Past Decade-A Nationwide Longitudinal Study.Pediatric cardiology · 2025Article
- Quality of Life and Well-Being in Adults With Fontan Physiology: Findings From the Australian and New Zealand Fontan Registry Quality of Life Study.Journal of the American Heart Association · 2024Article
- Social Determinants of Health Including Child Opportunity Index Leading to Gaps in Care for Patients With Significant Congenital Heart Disease.Journal of the American Heart Association · 2024Article
- Home-based long-term physical endurance and inspiratory muscle training in children and adults with Fontan circulation.Frontiers in cardiovascular medicine · 2024Article
- Design and rationale of re-energize fontan: Randomized exercise intervention designed to maximize fitness in fontan patients.American heart journal · 2023Article
- Fontan Geometry and Hemodynamics Are Associated With Quality of Life in Adolescents and Young Adults.The Annals of thoracic surgery · 2022Article
- Patient and Family Experience in a Multidisciplinary Clinic for Children With Single-Ventricle Heart Disease.Journal of patient experience · 2020Review
- Exploring the influence of socio-cultural factors and environmental resources on the health related quality of life of children and adolescents after congenital heart disease surgery: parental perspectives from a low middle income country.Journal of patient-reported outcomes · 2020Article
- Translation of the Frailty Paradigm from Older Adults to Children with Cardiac Disease.Pediatric cardiology · 2020Article
- Longitudinal study of anthropometry in Fontan survivors: Pediatric Heart Network Fontan study.American heart journal · 2020Article
- Emotional quality-of-life and patient-reported limitation in sports participation in children with uncorrected congenital and acquired heart disease in healthcare-restricted settings in low- and middle-income countries.Cardiology in the young · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectivesTo assess self-reported quality of life (QOL) in a large multicenter cohort of adolescent and young adults surviving Fontan. STUDY
designCross-sectional. The Pediatric Quality of Life Inventory (PedsQL) was administered to 408 survivors of Fontan ages 13-25 years enrolled in the Pediatric Heart Network Fontan Follow-up Study. Subjects also completed either the Child Health Questionnaire (age <19 years) or Short Form Health Survey (age ≥ 19 years). PedsQL data were compared with matched controls without a chronic health condition. Correlations between the measures were examined.
resultsMean PedsQL scores for subjects receiving Fontan were significantly lower than those for the control group for physical and psychosocial QOL (P < .001). Overall, 45% of subjects receiving Fontan had scores in the clinically significant impaired range for physical QOL with 30% in the impaired range for psychosocial QOL. For each 1 year increase in age, the physical functioning score decreased by an average of 0.76 points (P = .004) and the emotional functioning score decreased by an average of 0.64 points (P = .03). Among subjects ≥19 years of age, the physical functioning score decreased by an average of 2 points for each year increase in age (P = .02). PedsQL scale scores were significantly correlated with conceptually related Child Health Questionnaire (P < .001) and Short Form Health Survey scores (P < .001).
conclusionsSurvivors of Fontan are at risk for significantly impaired QOL which may decline with advancing age. Routine assessment of QOL is essential to inform interventions to improve health outcomes. The PedsQL allowed QOL assessment from pediatrics to young adulthood.
trial registrationClinicalTrials.gov: NCT00132782.
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Registered trials
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