Evidence map›Paper›PMID 26684632›Full record

ArticleInternational journal of immunopathology and pharmacology2016

Genetic polymorphisms and the development of invasive bacterial infections in children.

Susanna Esposito, Samantha Bosis, Annalisa Orenti, Silvia Spena, Valentina Montinaro, Sonia Bianchini, Alberto Zampiero, Nicola Principi

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06985160 (Association Between Single Nucleotide Polymorphisms in TLR4, LTA and RFP175 Genes and Susceptibility to Invasive Bacterial Infections in Infants Under 3 Months of Age), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06985160 nacompletednot on this mapstarted 2020, after this paper: background citation

Association Between Single Nucleotide Polymorphisms in TLR4, LTA and RFP175 Genes and Susceptibility to Invasive Bacterial Infections in Infants Under 3 Months of Age

TypeinterventionalSponsorEge UniversityRan2020 to 2024Enrolled200ConditionsPolymorphism, Genetic, Bacterial Infections, InfantArmsSpecific single nucleotide polymorphisms
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Susanna EspositoPediatric High Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy susanna.esposito@unimi.it.
Samantha BosisPediatric High Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Annalisa OrentiUnit of Medical Statistics, Biometry and Bioinformatics "G.A. Maccacaro", Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Silvia SpenaPediatric High Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Valentina MontinaroPediatric High Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Sonia BianchiniPediatric High Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Alberto ZampieroPediatric High Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Nicola PrincipiPediatric High Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate the associations between single nucleotide polymorphisms (SNPs) of factors involved in the development of invasive bacterial disease (IBD) in children, 47 SNPs of 18 candidate genes were analysed in 49 children with IBD and 100 controls. The G/T genotype of TLR2 rs2149356 and the C genotype of LTA rs2229094 were associated with significantly reduced risk of developing IBD (P=0.04 and P=0.05, respectively), whereas the C/T genotype of RFP175 rs1585110 was associated with a significantly higher risk of developing IBD (P=0.02). These results support the evidence that some genetic variants of factors involved in innate immunity may influence IBD risk in children.

Indexed as

Polymorphism, Single NucleotideAdolescentBacterial InfectionsChildChild, PreschoolFemaleHumansImmunity, InnateLymphotoxin-alphaMaleProspective StudiesToll-Like Receptor 2Toll-Like Receptor 4Lymphotoxin-alphaTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4adaptive immunitygenetic polymorphismsinnate immunityinvasive bacterial diseaseNeisseria meningitidissepsisStreptococcus pneumoniae

Identifiers

PMID26684632
PMCPMC5806737
OpenAlexW2272926885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.