ArticleJournal of neuroscience methods2016
A novel technique for quantitative bedside monitoring of neurovascular coupling.
Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Cerebral Near Infrared Spectroscopy Monitoring in Term Infants With Hypoxic Ischemic Encephalopathy-A Systematic Review.Frontiers in neurology · 2020Pooled it
- Data-driven wavelet coherence approach to assess neurovascular coupling in neonatal hypoxic-ischemic encephalopathy.Neurophotonics · 2026Article
- Feature fusion analysis approach based on synchronous EEG-fNIRS signals: application in etomidate use disorder individuals.Biomedical optics express · 2025Article
- Multimodal fNIRS-EEG sensor fusion: Review of data-driven methods and perspective for naturalistic brain imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Detection and Severity Identification of Neonatal Seizure Using Deep Convolutional Neural Networks from Multichannel EEG Signal.Pediatric health, medicine and therapeutics · 2023Article
- Concurrent fNIRS and EEG for Brain Function Investigation: A Systematic, Methodology-Focused Review.Sensors (Basel, Switzerland) · 2022Review
- Functional connectivity for the language network in the developing brain: 30 weeks of gestation to 30 months of age.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates with Asphyxia.Advances in experimental medicine and biology · 2022Article
- Role of Optical Neuromonitoring in Neonatal Encephalopathy-Current State and Recent Advances.Frontiers in pediatrics · 2021Review
- Cerebral Blood Flow Monitoring in High-Risk Fetal and Neonatal Populations.Frontiers in pediatrics · 2021Review
- Neural Activity and Decoding of Action Observation Using Combined EEG and fNIRS Measurement.Frontiers in human neuroscience · 2019Article
- Measurement of Neurovascular Coupling in Neonates.Frontiers in physiology · 2019Review
- Simultaneous functional near-infrared spectroscopy and electroencephalography for monitoring of human brain activity and oxygenation: a review.Neurophotonics · 2017Review
- Effect of electrocardiogram interference on cortico-cortical connectivity analysis and a possible solution.Journal of neuroscience methods · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is no current method for continuous quantification of neurovascular coupling (NVC) in spontaneous brain activity. To fill this void, we propose a novel method to quantify NVC using electroencephalogram (EEG) and near-infrared spectroscopy (NIRS) data. NEW
methodSince EEG and NIRS measure physiologic changes occurring at different time scales, we bring them into a common dynamical time frame (DTF). To achieve this, we partition both signals into one-second epochs and calculate the standard deviation of the EEG and the average value of the NIRS for each epoch. We then quantify the NVC by calculating spectral coherence between the two signals in the DTF. The resulting NVC will have a low resolution with all of its content localized below 1Hz.
resultsAfter validating this framework on simulated data, we applied this approach to EEG and NIRS signals collected from four term infants undergoing therapeutic hypothermia for neonatal encephalopathy. Two of these infants showed no evidence of structural brain injury, and the other two died during the course of the therapy. The intact survivors showed emergence of NVC during hypothermia and/or after rewarming. In contrast, the two critically ill infants, who subsequently died, lacked this feature. COMPARISON WITH EXISTING
methodsExisting methods quantify NVC by averaging neurovascular signals based on certain events (for example seizure) in the EEG activity, whereas our approach quantifies coupling between spontaneous background EEG and NIRS.
conclusionReal-time continuous monitoring of NVC may be a promising physiologic signal for cerebral monitoring in future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.