ReviewReproductive biology and endocrinology : RB&E2015
Parturition dysfunction in obesity: time to target the pathobiology.
Review in Reproductive biology and endocrinology : RB&E, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Influence of Maternal Obesity on Labor Induction: A Systematic Review and Meta-Analysis.Journal of midwifery & women's health · 2019Pooled it
- Impact of obesity on uterine contractile activity during labour: A blinded analysis of a randomised controlled trial cohort.BJOG : an international journal of obstetrics and gynaecology · 2022Trial
- Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes.Molecular and cellular pediatrics · 2026Article
- Lipidomics of prolonged labor duration in African American birthing people.Scientific reports · 2026Article
- The Safety of Two Different Oral Misoprostol Dosing Strategies for Labor Preinduction at Term: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Machine Learning Prediction of Intrapartum Cesarean Delivery in Women with Obesity.Journal of clinical medicine · 2026Article
- FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Risk associated with planned mode of delivery in women with obesity: a large population-based retrospective cohort study.International journal of obesity (2005) · 2025Article
- Adiponectin and Glucocorticoids Modulate Risk for Preterm Birth: The Healthy Start Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Maternal obesity in low-resource settings: a multicenter cohort study of labor and neonatal outcomes in Guinea.Frontiers in medicine · 2025Article
- Association Between Pre-Pregnancy Body Mass Index and Labor Induction Success Rates: A Case Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Obese mice have decreased uterine contractility and altered energy metabolism in the uterus at term gestation†.Biology of reproduction · 2024Article
- Effect of Obesity on Aquaporin5 Expression in Human Placental and Uterus Tissues.Journal of clinical medicine · 2024Article
- Assessment of women's needs, wishes and preferences regarding interprofessional guidance on nutrition in pregnancy - a qualitative study.BMC pregnancy and childbirth · 2024Article
- Article
- Prepregnancy obesity and risk of placental inflammation at term: a selection bias analysis.Annals of epidemiology · 2023Article
- Excessive Pregestational Weight and Maternal Obstetric Complications: The Role of Adipokines.International journal of molecular sciences · 2023Review
- The Relationship Between Uterine Activity, Oxytocin Dosing, Labor Progress, and Mode of Birth in Nulliparas with Obesity: Minimal Usefulness of Montevideo Unit Measurement.Biological research for nursing · 2023Article
- The Pathophysiology of Labor Dystocia: Theme with Variations.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study.Open medicine (Warsaw, Poland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Over a third of women of childbearing age in the United States are obese, and during pregnancy they are at increased risk for delayed labor onset and slow labor progress that often results in unplanned cesarean delivery. The biology behind this dysfunctional parturition is not well understood. Studies of obesity-induced changes in parturition physiology may facilitate approaches to optimize labor in obese women. In this review, we summarize known and proposed biologic effects of obesity on labor preparation, contraction/synchronization, and endurance, drawing on both clinical observation and experimental data. We present evidence from human and animal studies of interactions between obesity and parturition signaling in all elements of the birth process, including: delayed cervical ripening, prostaglandin insensitivity, amniotic membrane strengthening, decreased myometrial oxytocin receptor expression, decreased myocyte action potential initiation and contractility, decreased myocyte gap junction formation, and impaired myocyte neutralization of reactive oxygen species. We found convincing clinical data on the effect of obesity on labor initiation and successful delivery, but few studies on the underlying pathobiology. We suggest research opportunities and therapeutic interventions based on plausible biologic mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.