ReviewCold Spring Harbor perspectives in biology2015
Exploring Memory Representations with Activity-Based Genetics.
Review in Cold Spring Harbor perspectives in biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day.PLoS biology · 2025Article
- CCR5 closes the temporal window for memory linking.Nature · 2022Article
- Neurogenic Interventions for Fear Memory via Modulation of the Hippocampal Function and Neural Circuits.International journal of molecular sciences · 2022Review
- Dynamic and heterogeneous neural ensembles contribute to a memory engram.Current opinion in neurobiology · 2021Review
- Hippocampal neurons with stable excitatory connectivity become part of neuronal representations.PLoS biology · 2020Article
- Subregion-specific rules govern the distribution of neuronal immediate-early gene induction.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Deletion ofeLife · 2020Article
- Neuronal ensemble-specific DNA methylation strengthens engram stability.Nature communications · 2020Article
- Dissecting Neuronal Activation on a Brain-Wide Scale With Immediate Early Genes.Frontiers in neuroscience · 2020Review
- Mushroom Body Specific Transcriptome Analysis Reveals Dynamic Regulation of Learning and Memory Genes After Acquisition of Long-Term Courtship Memory inG3 (Bethesda, Md.) · 2018Article
- The role of the gustatory cortex in incidental experience-evoked enhancement of later taste learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Article
- The dynamic nature of fear engrams in the basolateral amygdala.Brain research bulletin · 2018Review
- Replay of large-scale spatio-temporal patterns from waking during subsequent NREM sleep in human cortex.Scientific reports · 2017Article
- Bidirectional Modulation of Intrinsic Excitability in Rat Prelimbic Cortex Neuronal Ensembles and Non-Ensembles after Operant Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cortical and amygdalar neuronal ensembles in alcohol seeking, drinking and withdrawal.Neuropharmacology · 2017Review
- The influence of low-level stimulus features on the representation of contexts, items, and their mnemonic associations.NeuroImage · 2017Article
- Brain-wide maps ofLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The brain is thought to represent specific memories through the activity of sparse and distributed neural ensembles. In this review, we examine the use of immediate early genes (IEGs), genes that are induced by neural activity, to specifically identify and genetically modify neurons activated naturally by environmental experience. Recent studies using this approach have identified cellular and molecular changes specific to neurons activated during learning relative to their inactive neighbors. By using opto- and chemogenetic regulators of neural activity, the neurons naturally recruited during learning can be artificially reactivated to directly test their role in coding external information. In contextual fear conditioning, artificial reactivation of learning-induced neural ensembles in the hippocampus or neocortex can substitute for the context itself. That is, artificial stimulation of these neurons can apparently cause the animals to "think" they are in the context. This represents a powerful approach to testing the principles by which the brain codes for the external world and how these circuits are modified with learning.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.